| Vitamin D Insufficiency and Deficiency among HIV-1-Infected Patients in a Tropical Setting. | |
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MedLine Citation:
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PMID: 22247338 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Vitamin D plays role in bone health and the regulation of the immune system. A cross-sectional study of serum 25-hydroxyvitamin D (25[OH]D) levels was conducted among HIV-1-infected Thai patients to determine the prevalence and associated factors of low vitamin D levels (25[OH]D <30 ng/mL) in tropical setting. 25-Hydroxyvitamin D was measured by liquid chromatography/tandem mass spectrometry. Of 178 patients, 58% received antiretroviral therapy at median (interquartile range [IQR]) duration of 7.4 (5.9-8.5) years. The prevalence of 25(OH)D deficiency (<20 ng/mL) and insufficiency (20-29.9 ng/mL) was 26.8% and 44.9%, respectively. Multivariate analysis showed that receiving efavirenz (EFV) was significantly associated with low vitamin D status (odds ratio = 3.60; 95% confidence interval, 1.06-12.15, P <.05). The mean (±standard deviation) level of 25(OH)D in patients receiving and not receiving EFV was 22.9 (6.6) and 28.6 (10.7) ng/mL, respectively, (P <.05). Low vitamin D status is common and needs to be assessed among HIV-infected patients including tropical residents especially when EFV is used. |
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Authors:
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Surasak Wiboonchutikul; Somnuek Sungkanuparph; Sasisopin Kiertiburanakul; La-Or Chailurkit; Angkana Charoenyingwattana; Wittaya Wangsomboonsiri; Wasun Chantratita; Boonsong Ongphiphadhanakul |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Volume: - ISSN: 1545-1097 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101185740 Medline TA: J Int Assoc Physicians AIDS Care (Chic) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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