Document Detail


Vitamin D: epidemiology of cardiovascular risks and events.
MedLine Citation:
PMID:  21872804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D may influence blood pressure through the renin-angiotensin system, parathyroid hormone levels, myocardial function, inflammation, and vascular calcification. In the past several years, a number of high-quality prospective studies have examined 25(OH)vitamin D (25(OH)D) levels in relation to risk of cardiovascular disease (CVD). Studies consistently show that levels of 25(OH)D below 20-25 ng/mL are associated with an increased risk of CVD incidence or mortality. Risk appears especially elevated at 25(OH)D levels below 10 or 15 ng/mL. It is unclear if levels higher that 25 ng/mL provide further benefits for CVD disease. Currently, results from randomized clinical trials are sparse and do not allow a definitive conclusion. Given other potential benefits of vitamin D, and low potential for toxicity, deficient levels below 25-30 ng/mL should be avoided and treated when identified. Further observational and randomized clinical trial data are important to better characterize the optimal range for 25(OH)D.
Authors:
Monica Leu; Edward Giovannucci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  25     ISSN:  1878-1594     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-01-03     Revised Date:  2012-11-07    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  633-46     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, Stockholm, Sweden. monica.leu@ki.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / epidemiology*,  etiology,  metabolism,  prevention & control
Humans
Risk Factors
Vitamin D / metabolism*,  therapeutic use
Vitamin D Deficiency / physiopathology*,  prevention & control,  therapy
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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