| Vitamin D and diabetes. | |
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MedLine Citation:
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PMID: 20511061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 1 (T1D) and type 2 (T2D) diabetes are considered multifactorial diseases in which both genetic predisposition and environmental factors participate in their development. Many cellular, preclinical, and observational studies support a role for vitamin D in the pathogenesis of both types of diabetes including: (1) T1D and T2D patients have a higher incidence of hypovitaminosis D; (2) pancreatic tissue (more specifically the insulin-producing beta-cells) as well as numerous cell types of the immune system express the vitamin D receptor (VDR) and vitamin D-binding protein (DBP); and (3) some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose (in)tolerance, insulin secretion, and sensitivity, as well as inflammation. Moreover, pharmacologic doses of 1,25-dihydroxyvitamin D (1,25(OH)(2)D), the active form of vitamin D, prevent insulitis and T1D in nonobese diabetic (NOD) mice and other models of T1D, possibly by immune modulation as well as by direct effects on beta-cell function. In T2D, vitamin D supplementation can increase insulin sensitivity and decrease inflammation. This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications. |
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Authors:
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Tatiana Takiishi; Conny Gysemans; Roger Bouillon; Chantal Mathieu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 39 ISSN: 1558-4410 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 419-46, table of contents Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Katholieke Universiteit Leuven, UZ Gasthuisberg, O&N I Herestraat, Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Type 1 / drug therapy*, prevention & control Diabetes Mellitus, Type 2 / drug therapy*, prevention & control Dietary Supplements Female Genetic Predisposition to Disease / genetics Glucose Intolerance / drug therapy Humans Immune System / drug effects, metabolism Insulin / secretion Insulin Resistance / genetics Insulin-Secreting Cells / metabolism Male Mice Pancreatitis / drug therapy, prevention & control Rats Receptors, Calcitriol / genetics, metabolism Vitamin D / analogs & derivatives*, blood, genetics, metabolism, therapeutic use* Vitamin D Deficiency / drug therapy*, genetics Vitamin D-Binding Protein / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Calcitriol; 0/Vitamin D-Binding Protein; 11061-68-0/Insulin; 1406-16-2/Vitamin D; 66772-14-3/1,25-dihydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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