Document Detail


Vitamin D, blood pressure, and African Americans: toward a unifying hypothesis.
MedLine Citation:
PMID:  20651156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D deficiency has increasingly been recognized in the general population and especially in African Americans whose deep skin pigmentation makes vitamin D photosynthesis inefficient. Over the last decade there has been increasing interest in the role that vitamin D deficiency may play in BP modulation because many epidemiologic studies have shown an inverse association between serum vitamin D concentration and BP. There is a high prevalence of vitamin D deficiency in African Americans who also have an increased susceptibility to develop hypertension and its consequences. This paper will review the circumstances leading to vitamin D deficiency in the African American population and will also discuss how vitamin D deficiency can affect the renin-angiotensin system, free radical production, inflammatory processes, and carbohydrate tolerance that in turn influence vascular endothelial function and vascular structure producing increased vascular resistance. It will speculate that the presence of vitamin D deficiency throughout life from its earliest phases may adversely affect the microvasculature in African Americans, thereby playing a major role in the genesis and maintenance of hypertension.
Authors:
Stephen G Rostand
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-22
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  5     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1697-703     Citation Subset:  IM    
Affiliation:
The Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. srostand@uab.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans*
Blood Pressure*
Calcium / metabolism
Homeostasis
Humans
Hypertension / ethnology,  etiology*,  metabolism,  physiopathology
Insulin Resistance
Microcirculation
Parathyroid Hormone / metabolism
Risk Assessment
Risk Factors
Vitamin D / metabolism*
Vitamin D Deficiency / complications*,  ethnology,  metabolism,  physiopathology
Chemical
Reg. No./Substance:
0/PTH protein, human; 0/Parathyroid Hormone; 1406-16-2/Vitamin D; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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