Document Detail


Vitamin C: update on physiology and pharmacology.
MedLine Citation:
PMID:  19508394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although ascorbic acid is an important water-soluble antioxidant and enzyme cofactor in plants and animals, humans and some other species do not synthesize ascorbate due to the lack of the enzyme catalyzing the final step of the biosynthetic pathway, and for them it has become a vitamin. This review focuses on the role of ascorbate in various hydroxylation reactions and in the redox homeostasis of subcellular compartments including mitochondria and endoplasmic reticulum. Recently discovered functions of ascorbate in nucleic acid and histone dealkylation and proteoglycan deglycanation are also summarized. These new findings might delineate a role for ascorbate in the modulation of both pro- and anti-carcinogenic mechanisms. Recent advances and perspectives in therapeutic applications are also reviewed. On the basis of new and earlier observations, the advantages of the lost ability to synthesize ascorbate are pondered. The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for ascorbate in the treatment of various diseases.
Authors:
J Mandl; A Szarka; G Bánhegyi
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-05
Journal Detail:
Title:  British journal of pharmacology     Volume:  157     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2010-01-14     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1097-110     Citation Subset:  IM    
Affiliation:
Department of Medical Chemistry, Molecular Biology and Patobiochemistry, Semmelweis University Budapest, Budapest, Hungary. mandl@puskin.sote.hu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticarcinogenic Agents / pharmacology,  therapeutic use
Antioxidants / pharmacology,  therapeutic use
Ascorbic Acid / pharmacology,  physiology*,  therapeutic use
Cell Transformation, Neoplastic / metabolism
Dealkylation
Endoplasmic Reticulum / metabolism
Glypicans / physiology
Histones / metabolism
Humans
Hydroxylation
Mitochondria / metabolism
Nucleic Acids / metabolism
Organelles / metabolism
Oxidation-Reduction
Proteoglycans / metabolism
Scurvy / drug therapy
Vitamins / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Antioxidants; 0/Glypicans; 0/Histones; 0/Nucleic Acids; 0/Proteoglycans; 0/Vitamins; 50-81-7/Ascorbic Acid
Comments/Corrections

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