| Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication. | |
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MedLine Citation:
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PMID: 12417278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication. |
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Authors:
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Antonio Silvestro; Francesco Scopacasa; Gabriella Oliva; Tiziana de Cristofaro; Luigi Iuliano; Gregorio Brevetti |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Atherosclerosis Volume: 165 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2003-05-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 277-83 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Naples "Federico II", Naples, Italy. antoniosilvestro@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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therapeutic use* Ascorbic Acid / therapeutic use* Brachial Artery / physiology Endothelium, Vascular / drug effects*, metabolism, physiology Exercise / physiology* Exercise Test Female Humans Intercellular Adhesion Molecule-1 / blood* Intermittent Claudication / blood*, prevention & control* Male Middle Aged Oxidative Stress / physiology* Treatment Outcome Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 126547-89-5/Intercellular Adhesion Molecule-1; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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