Document Detail

Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication.
MedLine Citation:
PMID:  12417278     Owner:  NLM     Status:  MEDLINE    
In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication.
Antonio Silvestro; Francesco Scopacasa; Gabriella Oliva; Tiziana de Cristofaro; Luigi Iuliano; Gregorio Brevetti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Atherosclerosis     Volume:  165     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-05-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Department of Medicine, University of Naples "Federico II", Naples, Italy.
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MeSH Terms
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use*
Brachial Artery / physiology
Endothelium, Vascular / drug effects*,  metabolism,  physiology
Exercise / physiology*
Exercise Test
Intercellular Adhesion Molecule-1 / blood*
Intermittent Claudication / blood*,  prevention & control*
Middle Aged
Oxidative Stress / physiology*
Treatment Outcome
Reg. No./Substance:
0/Antioxidants; 126547-89-5/Intercellular Adhesion Molecule-1; 50-81-7/Ascorbic Acid

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