Document Detail

Vitamin C decreases intracellular calcium level in human lymphoid cells.
MedLine Citation:
PMID:  11453107     Owner:  NLM     Status:  MEDLINE    
Human lymphocytes have low levels of many antioxidant enzymes however they are know to concentrate vitamin C. Cell injury, including oxidative stress effects, is associated with calcium influx so the influence of vitamin C on the maintenance of calcium levels in leukocytes was studied. Incubation of Molt-3 human lymphoblastoid cells with physiologically relevant concentrations of vitamin C and the calcium ionophore A23187 reversed the calcium influx and increased nuclear protein level associated with the ionophore alone. It is concluded that intracellular vitamin C can inhibit calcium influx into leukocytes so helping to minimise cell damage.
G Oztürk; C W Mulholland; B M Hannigan
Related Documents :
9333127 - Effect of metabolic acidosis on the potassium content of bone.
16109137 - Introduction to sevelamer hydrochloride and its clinical effects.
2801937 - Effects of chronic metabolic alkalosis on ca2+, pth and 1,25(oh)2d3 in the rat.
8322837 - Relative hypoparathyroidism and calcitriol up-regulation in hypercalciuric calcium rena...
7895927 - Direct contractile effect of endothelin-1 on isolated circular smooth muscle cells of g...
14691057 - Effects of chloride channel blockers on hypotonicity-induced contractions of the rat tr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  52     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  285-92     Citation Subset:  IM    
University of Gazi, Faculty of Medicine, Department of Physiology, Beşevler-Ankara-Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Calcimycin / pharmacology
Calcium / antagonists & inhibitors*,  metabolism*
Cell Line, Transformed
Intracellular Fluid / drug effects*,  metabolism
Ionophores / pharmacology
Lymphocytes / drug effects*,  metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Ionophores; 50-81-7/Ascorbic Acid; 52665-69-7/Calcimycin; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fever induced oxidative stress: the effect on thyroid status and the 5'-monodeiodinase activity, pro...
Next Document:  The evaluation of murine pleural lavage fluid cellular composition in experimental hemorrhagic shock...