Document Detail


Vitamin C decreases intracellular calcium level in human lymphoid cells.
MedLine Citation:
PMID:  11453107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human lymphocytes have low levels of many antioxidant enzymes however they are know to concentrate vitamin C. Cell injury, including oxidative stress effects, is associated with calcium influx so the influence of vitamin C on the maintenance of calcium levels in leukocytes was studied. Incubation of Molt-3 human lymphoblastoid cells with physiologically relevant concentrations of vitamin C and the calcium ionophore A23187 reversed the calcium influx and increased nuclear protein level associated with the ionophore alone. It is concluded that intracellular vitamin C can inhibit calcium influx into leukocytes so helping to minimise cell damage.
Authors:
G Oztürk; C W Mulholland; B M Hannigan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  52     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  285-92     Citation Subset:  IM    
Affiliation:
University of Gazi, Faculty of Medicine, Department of Physiology, Beşevler-Ankara-Turkey. Ozturk@med.gazi.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Calcimycin / pharmacology
Calcium / antagonists & inhibitors*,  metabolism*
Cell Line, Transformed
Humans
Intracellular Fluid / drug effects*,  metabolism
Ionophores / pharmacology
Lymphocytes / drug effects*,  metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Ionophores; 50-81-7/Ascorbic Acid; 52665-69-7/Calcimycin; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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