Document Detail


Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid.
MedLine Citation:
PMID:  20588054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Vitamin C transporter proteins SVCT1 and SVCT2 are required for the absorption and transport of vitamin C in humans. This study aims to determine whether common SVCT genotypes modify the association between dietary vitamin C and serum ascorbic acid.
METHODS: Non-smoking men and women (n=1,046) aged 20-29 were participants of the Toronto Nutrigenomics and Health Study. Overnight fasting blood samples were collected to determine serum ascorbic acid concentrations by HPLC and to genotype for two SVCT1 (rs4257763 and rs6596473) and two SVCT2 (rs6139591 and rs2681116) polymorphisms.
RESULTS: No diet-gene interactions were observed for the vitamin C transporter polymorphisms, however, the average (mean+/-SE) serum ascorbic acid concentrations differed between rs4257763 genotypes (GG: 24.4+/-1.3, GA: 26.8+/-1.1, AA: 29.7+/-1.4 micromol/l; p=0.002). For this polymorphism, the correlation between dietary vitamin C and serum ascorbic acid was only significant in subjects with a G allele. The SVCT2 polymorphisms also appeared to modify the strength of the diet-serum correlation.
CONCLUSIONS: Our findings demonstrate that genetic variation in SVCT1 can influence serum ascorbic acid concentrations and that SVCT1 and SVCT2 genotypes modify the strength of the correlation between dietary vitamin C and serum ascorbic acid.
Authors:
Leah E Cahill; Ahmed El-Sohemy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-30
Journal Detail:
Title:  Journal of nutrigenetics and nutrigenomics     Volume:  2     ISSN:  1661-6499     ISO Abbreviation:  J Nutrigenet Nutrigenomics     Publication Date:  2009  
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-12-10     Revised Date:  2011-01-21    
Medline Journal Info:
Nlm Unique ID:  101299758     Medline TA:  J Nutrigenet Nutrigenomics     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  292-301     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Department of Nutritional Sciences, University of Toronto, Toronto, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Ascorbic Acid / blood*,  metabolism*
Blood Pressure
Cholesterol, HDL / metabolism
Cross-Sectional Studies
Dietary Supplements
Female
Genotype
Humans
Male
Organic Anion Transporters, Sodium-Dependent / genetics*
Polymorphism, Genetic*
Seasons
Symporters / genetics*
Young Adult
alpha-Tocopherol / blood
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Organic Anion Transporters, Sodium-Dependent; 0/Symporters; 0/sodium-dependent vitamin C transporter; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol

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