Document Detail

Vitamin C and E intake is associated with increased paraoxonase activity.
MedLine Citation:
PMID:  12171796     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Paraoxonase (PON1), an esterase physically associated with high density lipoprotein, has been shown to inhibit atherogenic low density lipoprotein and high density lipoprotein oxidation. PON1 activity appears to be primarily under genetic control with some environmental modification and is a predictor of vascular disease. Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity. METHODS AND RESULTS: The vitamin C and E intakes of male white subjects (n=189) were estimated by using a standardized food frequency survey. With covariates, vitamin C or E intakes were found to be significant positive predictors of PON1 activity for the hydrolysis of paraoxon and diazoxon with the use of linear regression. Smoking and use of statins were independent predictors of PON1 activity. CONCLUSIONS: PON1 activity, which is primarily genotype dependent, varies with antioxidant vitamins, cigarette smoking, and statin drug use. Because PON1 activity is a better predictor of vascular disease than is the currently described genetic variation in PON1, further studies of the environmental influences on PON1 activity and additional PON1 genetic variants are warranted.
Gail P Jarvik; Nancey Trevanian Tsai; Laura A McKinstry; Roohi Wani; Victoria H Brophy; Rebecca J Richter; Gerard D Schellenberg; Patrick J Heagerty; Thomas S Hatsukami; Clement E Furlong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  22     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-12     Completed Date:  2002-09-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1329-33     Citation Subset:  IM    
Department of Medicine, Division of Medical Genetics, University of Washington 98195, USA.
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MeSH Terms
Aged, 80 and over
Antilipemic Agents / therapeutic use
Arteriosclerosis / metabolism,  prevention & control
Ascorbic Acid / administration & dosage*
Cholesterol, HDL / metabolism
Cholesterol, LDL / metabolism
Esterases / genetics,  metabolism*
Lipid Peroxidation
Middle Aged
Smoking / adverse effects
Vitamin E / administration & dosage*
Grant Support
Reg. No./Substance:
0/Antilipemic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; EC 3.1.-/Esterases; EC; EC protein, human
Comment In:
Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1248-50   [PMID:  12171781 ]

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