Document Detail


Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial.
MedLine Citation:
PMID:  20733448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate whether maternally administered vitamins C and E lower the risk of spontaneous preterm birth.
METHODS: This is a secondary analysis of a randomized, double-masked, placebo-controlled trial in nulliparous women at low-risk administered 1,000 mg vitamin C and 400 international units vitamin E or placebo daily from 9 to 16 weeks of gestation until delivery. Outcomes include preterm birth attributable to premature rupture of membranes (PROM) and total spontaneous preterm births (spontaneous preterm birth attributable to PROM or spontaneous labor).
RESULTS: Of the 10,154 women randomized, outcome data were available for 9,968 (4,992 vitamin group and 4,976 placebo group). A total of 1,038 women (10.4%) delivered preterm, of whom 698 (7.0%) had spontaneous preterm birth. A spontaneous preterm birth occurred in 356 women (7.1%) assigned to daily vitamin C and E supplementation and in 342 (6.9%) assigned to placebo. There were 253 women (2.5%) who delivered after preterm PROM and 445 (4.5%) after a spontaneous preterm labor. In women supplemented with vitamins C and E, births attributed to preterm PROM were similar at less than 37 and 35 weeks of gestation, but births were less frequent before 32 weeks of gestation (0.3% compared with 0.6%, adjusted odds ratio 0.3-0.9). However, total spontaneous preterm births across gestation in women supplemented with vitamins C and E or a placebo were similar.
CONCLUSION: Maternal supplementation with vitamins C and E beginning at 9 to 16 weeks of gestation in nulliparous women at low risk did not reduce spontaneous preterm births.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00135707.
LEVEL OF EVIDENCE: I.
Authors:
John C Hauth; Rebecca G Clifton; James M Roberts; Catherine Y Spong; Leslie Myatt; Kenneth J Leveno; Gail D Pearson; Michael W Varner; John M Thorp; Brian M Mercer; Alan M Peaceman; Susan M Ramin; Anthony Sciscione; Margaret Harper; Jorge E Tolosa; George Saade; Yoram Sorokin; Garland B Anderson;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-09-28     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-8     Citation Subset:  AIM; IM    
Affiliation:
Departments of Obstetrics and Gynecology at the University of Alabama at Birmingham, Birmingham, Alabama, USA. jchauth@uab.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00135707
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antioxidants / therapeutic use*
Ascorbic Acid / therapeutic use*
Dietary Supplements
Female
Fetal Membranes, Premature Rupture / prevention & control*
Humans
Pregnancy
Premature Birth / etiology,  prevention & control*
Vitamin E / therapeutic use*
Young Adult
Grant Support
ID/Acronym/Agency:
HD21410/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27869/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208/HD/NICHD NIH HHS; HD36801/HD/NICHD NIH HHS; HD40485/HD/NICHD NIH HHS; HD40500/HD/NICHD NIH HHS; HD40512/HD/NICHD NIH HHS; HD40544/HD/NICHD NIH HHS; HD40545/HD/NICHD NIH HHS; HD40560/HD/NICHD NIH HHS; HD53097/HD/NICHD NIH HHS; HD53118/HD/NICHD NIH HHS; M01 RR00080/RR/NCRR NIH HHS; R24 HD050924-07/HD/NICHD NIH HHS; U10 HD027869/HD/NICHD NIH HHS; U10 HD027869-21/HD/NICHD NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid
Comments/Corrections

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