Document Detail


Vitamin B6 and vitamin C status in elderly patients with infections during hospitalization.
MedLine Citation:
PMID:  9491189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have evaluated whether vitamin B6 and C metabolism may be altered by infection in the elderly. Vitamin B6 and C biochemical status has been assessed for times over a period of 21 days (days 0, 7, 14, and 21) in 18 subjects > or = 75 years. The subjects were divided into 3 groups: group I (8 subjects with acute infection), group II (4 malnourished subjects), and group III (6 control subjects). Vitamin B6 status was determined by plasma pyridoxal-5'-phosphate (PLP) and erythrocyte aspartate aminotransferase activation coefficient (alpha-EAST), and vitamin C status by plasma ascorbic acid. During the 3 weeks, vitamins B6 and C values were significantly different between groups: at days 7 and 14, PLP values were significantly higher in group III than in both groups I and II, and alpha-EAST values were significantly higher in group I than in both groups II and III. Plasma ascorbate values were significantly lower in group I than in both groups II and III. These data suggest that an acute catabolic state like infection may influence vitamin B6 and C metabolism. Nevertheless, more work is needed to assert that vitamin B6 and C supplementation may be useful during infection.
Authors:
P Pfitzenmeyer; J C Guilland; P d'Athis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  41     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1997  
Date Detail:
Created Date:  1998-03-06     Completed Date:  1998-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  344-52     Citation Subset:  IM    
Affiliation:
Service de Médecine Gériatrique, Centre Hospitalier et Universitaire, Dijon, France.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / metabolism
Aged
Aged, 80 and over
Ascorbic Acid / metabolism*
Cross Infection / metabolism*
Female
Humans
Male
Nutrition Disorders / metabolism,  physiopathology
Pyridoxine / metabolism*
Time Factors
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 50-81-7/Ascorbic Acid; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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