Document Detail

Vitamin B6 suppresses growth of the feline mammary tumor cell line FRM.
MedLine Citation:
PMID:  16636479     Owner:  NLM     Status:  MEDLINE    
Growth of FRM cells was inhibited by the addition of pyridoxine in a dose-dependent manner. Use of 5 mM pyridoxine caused an almost complete arrest of cell growth. Pyridoxal was as effective as pyridoxine, but pyridoxamine showed weak inhibitory action. Electron-microscopic examination of control cells revealed large nuclei and cellular membranes with villi, but, in pyridoxine-treated cells, condensed or degraded nuclei were observed. Many vacuoles and cholesterol crystals were widely distributed inside the cellular membrane of pyridoxine-treated cells. One of the vacuoles was identified as a lipid droplet. The DNA ladder was observed in the pyridoxine-treated cells. It is suggested that pyridoxine treatment of FRM cells causes cytolysis of cells by apoptosis.
Dai Shimada; Ayumi Fukuda; Hiroaki Kanouchi; Mitsuharu Matsumoto; Tatsuzo Oka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  70     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-25     Completed Date:  2006-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1038-40     Citation Subset:  IM    
Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan.
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MeSH Terms
Apoptosis / drug effects
Breast Neoplasms / pathology*,  ultrastructure
Cell Line, Tumor
Microscopy, Electron
Vitamin B 6 / pharmacology*
Reg. No./Substance:
8059-24-3/Vitamin B 6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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