| Vitamin B12-induced reduction of platelet monoamine oxidase activity in patients with dementia and pernicious anaemia. | |
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MedLine Citation:
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PMID: 1829005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Platelet monoamine oxidase (MAO) activity has previously been shown to be increased in patients with senile dementia of Alzheimer type (SDAT) and in patients with megaloblastic anaemia. Moreover, low serum B12 levels were found to be 4-5 times more frequent in SDAT compared with an unselected population of similar age. In the present investigation, platelet MAO activity was estimated in 14 SDAT patients with relatively low serum B12 levels and in 4 patients with pernicious anaemia. Before B12 therapy, platelet MAO activity was significantly increased in both patient groups compared with a control group. After B12 therapy, platelet MAO activity was significantly reduced in both patient groups to apparently normal levels. The present results show that B12 status is a controlling factor of platelet MAO activity and confirm that a significant connection exists between vitamin B12 deficiency and primary degenerative dementia disorders, such as SDAT. |
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Authors:
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B Regland; C G Gottfries; L Oreland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European archives of psychiatry and clinical neuroscience Volume: 240 ISSN: 0940-1334 ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Publication Date: 1991 |
Date Detail:
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Created Date: 1991-08-01 Completed Date: 1991-08-01 Revised Date: 2009-05-11 |
Medline Journal Info:
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Nlm Unique ID: 9103030 Medline TA: Eur Arch Psychiatry Clin Neurosci Country: GERMANY |
Other Details:
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Languages: eng Pagination: 288-91 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, St. Jörgen's Hospital, University of Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / enzymology* Anemia, Pernicious / drug therapy, enzymology* Blood Platelets / drug effects, enzymology* Female Humans Hydroxocobalamin / administration & dosage* Injections, Intramuscular Male Monoamine Oxidase / blood* Vitamin B 12 / blood Vitamin B 12 Deficiency / drug therapy, enzymology* |
| Chemical | |
Reg. No./Substance:
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13422-51-0/Hydroxocobalamin; 68-19-9/Vitamin B 12; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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