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Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil.
MedLine Citation:
PMID:  21390459     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients.
METHOD: Cross-sectional study.
RESULTS: 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 patients (36.8%). Serum vitamin B12 levels were negatively associated with age (B = -3.17; β= -0.171; p = 0.037) and duration of metformin use (B= -33.36; β= -0.161; p = 0.048), and positively associated with the estimated intake of vitamin B12 (B= 67.96; β= 0.249; p = 0.002).
CONCLUSION: The present findings suggest a high prevalence of vitamin B12 deficiency in metformin-treated diabetic patients. Older patients, patients in long term treatment with metformin and low vitamin B12 intake are probably more prone to this deficiency.
Authors:
Monique Nervo; Adriano Lubini; Fabiana Viegas Raimundo; Gustavo Adolpho Moreira Faulhaber; Carine Leite; Leonardo Moura Fischer; Tania Weber Furlanetto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista da Associação Médica Brasileira (1992)     Volume:  57     ISSN:  0104-4230     ISO Abbreviation:  Rev Assoc Med Bras     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-03-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9308586     Medline TA:  Rev Assoc Med Bras     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
Affiliation:
Internal Medicine Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS.
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