Document Detail

Vitamin B12 and folate serum levels in newly admitted psychiatric patients.
MedLine Citation:
PMID:  16216392     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Deficiencies of cobalamin and folate may play a causal role in the development or exacerbation of psychiatric illnesses. We compared cobalamin and folate levels in newly admitted psychiatric patients to mentally healthy controls and assessed their correlation with various psychiatric conditions. METHODS: All patients consecutively admitted to a psychiatric hospital were examined for serum cobalamin and folate levels. Controls were obtained from a population with no known mental illness. Values were considered to be below normal if cobalamin was <223 pg/ml and folate <3.1 ng/ml. RESULTS: The 224 newly admitted patients did not differ significantly from controls, both with regard to the mean cobalamin level and to the prevalence of lower than normal levels. About 30% of patients had low folate values compared to 2.5% in the control group (P<0.0001). Mean folate level in controls was significantly higher than in patients (P<0.0001), where a positive correlation was found between low folate levels and depression. CONCLUSIONS: The results of our study suggest that folate levels be assessed in patients admitted to psychiatric wards, especially in those with depression. Further study is needed to evaluate the role of folate and cobalamin in psychiatric illness.
Vladimir Lerner; Michael Kanevsky; Tzvi Dwolatzky; Tsvi Rouach; Ram Kamin; Chanoch Miodownik
Publication Detail:
Type:  Journal Article     Date:  2005-10-10
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  25     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  60-7     Citation Subset:  IM    
Division of Psychiatry, Ministry of Health Mental Health Center, Faculty of Health Sciences Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
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MeSH Terms
Case-Control Studies
Depression / blood,  etiology
Folic Acid / blood*
Folic Acid Deficiency / complications,  epidemiology
Mental Disorders / blood*,  etiology
Mental Health
Middle Aged
Vitamin B 12 / blood*
Vitamin B 12 Deficiency / complications,  epidemiology
Vitamin B Complex / blood*
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

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