Document Detail

Vitamin B12 deficiency as a worldwide problem.
MedLine Citation:
PMID:  15189123     Owner:  NLM     Status:  MEDLINE    
Pernicious anemia is a common cause of megaloblastic anemia throughout the world and especially in persons of European or African descent. Dietary deficiency of vitamin B12 due to vegetarianism is increasing and causes hyperhomocysteinemia. The breast-fed infant of a vitamin B12-deficient mother is at risk for severe developmental abnormalities, growth failure, and anemia. Elevated methylmalonic acid and/or total homocysteine are sensitive indicators of vitamin B12-deficient diets and correlate with clinical abnormalities. Dietary vitamin B12 deficiency is a severe problem in the Indian subcontinent, Mexico, Central and South America, and selected areas in Africa. Dietary vitamin B12 deficiency is not prevalent in Asia, except in vegetarians. Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae.
Sally P Stabler; Robert H Allen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  24     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-10     Completed Date:  2004-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-326     Citation Subset:  IM    
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
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MeSH Terms
Anemia, Megaloblastic / epidemiology,  etiology
Anemia, Pernicious / epidemiology,  etiology
Biological Availability
Diet, Vegetarian / adverse effects
Hyperhomocysteinemia / epidemiology,  etiology
Intestinal Absorption
Vitamin B 12 / administration & dosage*,  pharmacokinetics
Vitamin B 12 Deficiency / complications*,  epidemiology*
World Health*
Reg. No./Substance:
68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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