Document Detail

Vitamin B12 (cobalamin) deficiency in elderly patients.
MedLine Citation:
PMID:  15289425     Owner:  NLM     Status:  MEDLINE    
Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.
Emmanuel Andrès; Noureddine Henoun Loukili; Esther Noel; Georges Kaltenbach; Maher Ben Abdelgheni; Anne Elisabeth Perrin; Marie Noblet-Dick; Frédéric Maloisel; Jean-Louis Schlienger; Jean-Frédéric Blicklé
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  171     ISSN:  0820-3946     ISO Abbreviation:  CMAJ     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-03     Completed Date:  2004-09-16     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  AIM; IM    
Department of Internal Medicine, Medical Clinic B, Strasbourg University Hospitals, Strasbourg, France.
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MeSH Terms
Geriatric Assessment*
Vitamin B 12 / metabolism,  therapeutic use
Vitamin B 12 Deficiency* / diagnosis,  drug therapy,  epidemiology,  etiology
Reg. No./Substance:
68-19-9/Vitamin B 12
Comment In:
CMAJ. 2005 Feb 15;172(4):448-50; author reply 451   [PMID:  15710919 ]
CMAJ. 2005 Feb 15;172(4):450-1; author reply 451   [PMID:  15710922 ]
CMAJ. 2005 Feb 15;172(4):450; author reply 451   [PMID:  15710923 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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