| Vitamin B12 (cobalamin) deficiency in elderly patients. | |
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MedLine Citation:
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PMID: 15289425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin B12 or cobalamin deficiency occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%-20% of all cases), insufficient dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency. |
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Authors:
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Emmanuel Andrès; Noureddine Henoun Loukili; Esther Noel; Georges Kaltenbach; Maher Ben Abdelgheni; Anne Elisabeth Perrin; Marie Noblet-Dick; Frédéric Maloisel; Jean-Louis Schlienger; Jean-Frédéric Blicklé |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 171 ISSN: 0820-3946 ISO Abbreviation: CMAJ Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-09-16 Revised Date: 2010-09-20 |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: Canada |
Other Details:
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Languages: eng Pagination: 251-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Medical Clinic B, Strasbourg University Hospitals, Strasbourg, France. emmanuel.andres@chru-strasbourg.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Geriatric Assessment* Humans Vitamin B 12 / metabolism, therapeutic use Vitamin B 12 Deficiency* / diagnosis, drug therapy, epidemiology, etiology |
| Chemical | |
Reg. No./Substance:
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68-19-9/Vitamin B 12 |
| Comments/Corrections | |
Comment In:
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CMAJ. 2005 Feb 15;172(4):450; author reply 451
[PMID:
15710923
]
CMAJ. 2005 Feb 15;172(4):448-50; author reply 451 [PMID: 15710919 ] CMAJ. 2005 Feb 15;172(4):450-1; author reply 451 [PMID: 15710922 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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