Document Detail

Vitamin B12 absorption capacity in healthy children.
MedLine Citation:
PMID:  3958854     Owner:  NLM     Status:  MEDLINE    
B12 absorption was investigated in 47 healthy children aged 7 months to 15.8 years (median 4.9 years). The patients had either recovered from giardiasis, the post-gastroenteritis syndrome, or had celiac disease in remission (treated with a gluten-free diet). The B12 absorption was measured by a double-isotope technique using 57CoB12 and 51CrCl3, the latter being the inabsorbable marker. The radiation dose was minimal. The results were presented as fractional absorption of B12 (FAB12). Within the different age groups, the absorption test was performed by means of the following oral amounts of B12: 0- less than 1 year, 0.5 microgram; 1-3 years: 1.7 micrograms, 4-6 years, 2.5 micrograms; 7-10 years; 3.3 micrograms; and 11-15 years, 4.5 micrograms. When using these oral amounts of B12, the medians (and ranges) of FAB12 were found to be: 1-3 years (n = 18), 37% (16-80%); 4-6 years (n = 10), 27% (19-40%); 7-10 years (n = 9), 32% (21-44%); and 11-15 years (n = 8), 27% (19-59%). The FAB12 in two children aged 7 and 11 months was 31% and 32%, respectively. These results may be interpretated as reference values for B12 absorption in children. Further absorption tests were performed in seven children representing the four age groups from 1 to 15 years. When a high oral amount of B12 was given (i.e., three times the saturation dose), the FAB12 ranged from 0 to 20% (median 9%), whereas a low amount (i.e., one-ninth of the saturation dose) produced fractional absorptions from 65 to 82% (median 74%).(ABSTRACT TRUNCATED AT 250 WORDS)
K Hjelt; P A Krasilnikoff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  5     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1986-05-13     Completed Date:  1986-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  274-7     Citation Subset:  IM    
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MeSH Terms
Age Factors
Child, Preschool
Chromium / diagnostic use
Chromium Compounds*
Cobalt Radioisotopes / diagnostic use
Intestinal Absorption*
Vitamin B 12 / metabolism*
Reg. No./Substance:
0/Chlorides; 0/Chromium Compounds; 0/Cobalt Radioisotopes; 10049-05-5/chromous chloride; 68-19-9/Vitamin B 12; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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