| Vitamin B-6 metabolism in premature infants. | |
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MedLine Citation:
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PMID: 1898584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The response of premature infants to intravenous pyridoxine or pyridoxal was studied by measuring serum and erythrocyte pyridoxal 5'-phosphate (PLP). In the first study serum PLP was measured in 28 infants periodically through day 28. Infants less than 30 wk gestational age (GA) had no serum PLP response to the administration of pyridoxine. Infants greater than or equal to 30 wk GA had significantly greater concentrations of PLP by day 3. In the second study there was a negligible response of serum PLP in nine infants less than or equal to 28 wk GA to supplementation of pyridoxine or pyridoxal. However, erythrocyte PLP and whole-blood total vitamin B-6 concentrations increased in both groups, indicating the presence of a substantial amount of the vitamin in the circulation of the infants. Whereas the functional significance of these observations is not known, it appears that in premature infants, serum PLP may not be an appropriate indicator of vitamin B-6 status. |
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Authors:
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D J Raiten; R D Reynolds; M B Andon; S T Robbins; A B Fletcher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 53 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-01-23 Completed Date: 1991-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: AIM; IM |
Affiliation:
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Children's Hospital National Medical Center, Washington, DC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Erythrocytes
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metabolism Gestational Age Humans Infant, Newborn Infant, Premature / metabolism* Parenteral Nutrition, Total Pyridoxal / administration & dosage Pyridoxal Phosphate / blood Pyridoxine / administration & dosage, blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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54-47-7/Pyridoxal Phosphate; 65-23-6/Pyridoxine; 66-72-8/Pyridoxal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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