Document Detail

Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.
MedLine Citation:
PMID:  23227234     Owner:  NLM     Status:  MEDLINE    
Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs492602) and TCN2 (rs1801198, rs9606756) that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child's IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8); after adjustment: 0.7 (95% CI -0.04, 1.4)). Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6). The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted.
Carolina Bonilla; Debbie A Lawlor; Amy E Taylor; David J Gunnell; Yoav Ben-Shlomo; Andrew R Ness; Nicholas J Timpson; Beate St Pourcain; Susan M Ring; Pauline M Emmett; A David Smith; Helga Refsum; Craig E Pennell; Marie-Jo Brion; George Davey Smith; Sarah J Lewis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-21     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e51084     Citation Subset:  IM    
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MeSH Terms
Confounding Factors (Epidemiology)
Dietary Supplements
Fetal Blood / metabolism
Genetic Association Studies
Great Britain
Intelligence Tests*
Longitudinal Studies
Mendelian Randomization Analysis*
Polymorphism, Single Nucleotide / genetics
Vitamin B 12 / blood*
Grant Support
076467//Wellcome Trust; 092731//Wellcome Trust; 74882//Medical Research Council; G0600705//Medical Research Council; G9815508//Medical Research Council; WT084668MA//Wellcome Trust
Reg. No./Substance:
P6YC3EG204/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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