Document Detail


Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.
MedLine Citation:
PMID:  23227234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs492602) and TCN2 (rs1801198, rs9606756) that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child's IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8); after adjustment: 0.7 (95% CI -0.04, 1.4)). Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6). The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted.
Authors:
Carolina Bonilla; Debbie A Lawlor; Amy E Taylor; David J Gunnell; Yoav Ben-Shlomo; Andrew R Ness; Nicholas J Timpson; Beate St Pourcain; Susan M Ring; Pauline M Emmett; A David Smith; Helga Refsum; Craig E Pennell; Marie-Jo Brion; George Davey Smith; Sarah J Lewis
Related Documents :
4066534 - Bovine embryo transfer pregnancies. ii. lengths of gestation.
14998964 - Zygote transfer on day 1 versus cleavage stage embryo transfer on day 3: a prospective ...
17335824 - Changes in olfactory function in pregnancy and postpartum.
9930294 - Strategies to prevent multiple pregnancies in assisted conception programmes.
15912414 - Pregnancy outcome after loop electrosurgical excision procedure for the management of c...
12962354 - Complications of second and third trimester pregnancies.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-21     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e51084     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Child
Confounding Factors (Epidemiology)
Dietary Supplements
Female
Fetal Blood / metabolism
Genetic Association Studies
Great Britain
Haplotypes
Humans
Intelligence Tests*
Longitudinal Studies
Male
Mendelian Randomization Analysis*
Parents*
Polymorphism, Single Nucleotide / genetics
Pregnancy
Vitamin B 12 / blood*
Grant Support
ID/Acronym/Agency:
076467//Wellcome Trust; 092731//Wellcome Trust; 74882//Medical Research Council; G0600705//Medical Research Council; G9815508//Medical Research Council; WT084668MA//Wellcome Trust
Chemical
Reg. No./Substance:
P6YC3EG204/Vitamin B 12
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elastase and tryptase govern TNF?-mediated production of active chemerin by adipocytes.
Next Document:  Use of NHANES data to link chemical exposures to chronic diseases: a cautionary tale.