Document Detail

Vital microscopy of islet blood flow: catecholamine effects in normal and ob/ob mice.
MedLine Citation:
PMID:  3101509     Owner:  NLM     Status:  MEDLINE    
The pancreatic microcirculation in noninbred ob/ob mice and normal controls was visualized in a fluorescence microscope and examined for responses to intravenous infusions of epinephrine or norepinephrine. Evaluations of coded video recordings revealed a smooth dose-response relationship and validated a semiquantitative method of analysis. In ob/ob mice the islet microcirculation was markedly and reversibly inhibited by 0.14-4 micrograms of epinephrine X min-1 X kg body wt-1; the flow was almost totally stopped at the highest infusion rates. Capillary flow in the exocrine pancreas appeared unaffected, except for some inhibition at 4.0 micrograms X min-1 X kg-1. Norepinephrine was less potent an inhibitor of islet blood flow. Normal lean mice exhibited minor responses to 1-11.3 micrograms of epinephrine X min-1 X kg-1; in most cases there was no visible effect. It is concluded that there is a selective regulation of blood flow through the endocrine portion of the pancreas and that the islet microcirculation is hypersensitive to catecholamines in noninbred ob/ob mice. A defective inhibitory influence from the brain may play a role in the development of excessive hyperinsulinemia in ob/ob mice.
P Rooth; I B Täljedal
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  252     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-02     Completed Date:  1987-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E130-5     Citation Subset:  IM    
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MeSH Terms
Epinephrine / pharmacology*
Islets of Langerhans / blood supply*,  cytology,  drug effects
Mice, Obese
Microscopy, Fluorescence
Norepinephrine / pharmacology*
Regional Blood Flow / drug effects
Species Specificity
Reg. No./Substance:
0/Fluoresceins; 0/Thiocyanates; 3326-32-7/Fluorescein-5-isothiocyanate; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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