| Vital microscopy of islet blood flow: catecholamine effects in normal and ob/ob mice. | |
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MedLine Citation:
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PMID: 3101509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pancreatic microcirculation in noninbred ob/ob mice and normal controls was visualized in a fluorescence microscope and examined for responses to intravenous infusions of epinephrine or norepinephrine. Evaluations of coded video recordings revealed a smooth dose-response relationship and validated a semiquantitative method of analysis. In ob/ob mice the islet microcirculation was markedly and reversibly inhibited by 0.14-4 micrograms of epinephrine X min-1 X kg body wt-1; the flow was almost totally stopped at the highest infusion rates. Capillary flow in the exocrine pancreas appeared unaffected, except for some inhibition at 4.0 micrograms X min-1 X kg-1. Norepinephrine was less potent an inhibitor of islet blood flow. Normal lean mice exhibited minor responses to 1-11.3 micrograms of epinephrine X min-1 X kg-1; in most cases there was no visible effect. It is concluded that there is a selective regulation of blood flow through the endocrine portion of the pancreas and that the islet microcirculation is hypersensitive to catecholamines in noninbred ob/ob mice. A defective inhibitory influence from the brain may play a role in the development of excessive hyperinsulinemia in ob/ob mice. |
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Authors:
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P Rooth; I B Täljedal |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 252 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-03-02 Completed Date: 1987-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E130-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Epinephrine / pharmacology* Female Fluorescein-5-isothiocyanate Fluoresceins Islets of Langerhans / blood supply*, cytology, drug effects Male Mice Mice, Obese Microscopy, Fluorescence Norepinephrine / pharmacology* Regional Blood Flow / drug effects Species Specificity Thiocyanates |
| Chemical | |
Reg. No./Substance:
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0/Fluoresceins; 0/Thiocyanates; 3326-32-7/Fluorescein-5-isothiocyanate; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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