Document Detail

Vital exhaustion in relation to lifestyle and lipid profile in healthy women.
MedLine Citation:
PMID:  12581947     Owner:  NLM     Status:  MEDLINE    
"Vital exhaustion," characterized by fatigue, irritability, and demoralization, precedes new and recurrent coronary events. Biological mechanisms explaining this association are not fully understood. The objective was to investigate the relationship between vital exhaustion, lifestyle, and lipid profile. Vital exhaustion, smoking, body mass index (BMI), alcohol consumption, exercise capacity, and serum lipids were determined in 300 healthy women, aged 56.4 +/- 7.1 years. No statistically significant associations were found between vital exhaustion and lifestyle variables. Divided into quartiles, vital exhaustion was inversely related to high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 in a linear fashion after adjustment for age, BMI, exercise capacity, and alcohol consumption. A multivariate-adjusted vital exhaustion-score in the top quartile, as compared to one in the lowest, was associated with 12% lower HDL-C and 8% lower apolipoprotein A1 (p < .05). In conclusion, alterations in lipid metabolism may be a possible mediating mechanism between vital exhaustion and coronary heart disease. The impact of lifestyle variables was weak.
Jenny C Koertge; Staffan Ahnve; Karin Schenck-Gustafsson; Kristina Orth-Gomer; Sarah P Wamala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of behavioral medicine     Volume:  10     ISSN:  1070-5503     ISO Abbreviation:  Int J Behav Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421097     Medline TA:  Int J Behav Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-55     Citation Subset:  IM    
Preventive Medicine, Department of Public Health Sciences, Karolinska Institute, Stokholm, Sweden.
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MeSH Terms
Alcohol Drinking / adverse effects
Apolipoprotein A-I / blood*
Body Mass Index
Cholesterol, HDL / blood*
Fatigue / psychology*
Heart Diseases / etiology*
Life Style*
Middle Aged
Risk Factors
Stress, Psychological*
Grant Support
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Cholesterol, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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