| Vital capacity and oxygen saturation at rest and after exercise predict hypoxemia during hypoxic inhalation test in patients with respiratory disease. | |
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MedLine Citation:
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PMID: 23278952 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND & OBJECTIVE: The hypoxic inhalation test (HIT) accurately predicts air travel hypoxemia, but availability is limited. We assessed whether oxygen saturation (SpO(2) ) during hypoxic inhalation test (HIT) can be predicted by simple measures of lung function and exercise induced hypoxemia. METHODS: Analysis of all patients who had HIT and lung function testing between January 2005 and April 2010. Prior to HIT, SpO(2) on room air was measured at rest and after 2 minutes of moderate exercise. HIT was conducted using FiO(2) 0.14 (simulating PiO(2) at 10,000ft altitude) and SpO(2) was measured after equilibration of ≥5 minutes. The relationships between SpO(2) during HIT (HIT SpO(2) ) and resting SpO(2) , post-exercise SpO(2) , gas exchange (DLCO) and ventilatory capacity were examined. Linear regression was performed to identify significant predictors of HIT SpO(2) . RESULTS: 137 patients were studied: 70 had COPD, 43 interstitial lung disease (ILD) and 20 extra-pulmonary restriction (EPR). All patients with HIT SpO(2) ≤85% had post-exercise SpO(2) <95% (n=24 (18%)). HIT SpO(2) correlated best with post-exercise SpO(2) overall and in ILD and EPR subgroups (r=0.69, 0.76 and 0.61, p<0.01). Linear regression identified FVC % predicted, resting SpO(2) , and post-exercise SpO(2) as independent predictors of HIT SpO(2) . CONCLUSIONS: In patients with respiratory disease, post-exercise SpO(2) ≥95% on room air may be used to exclude the need for HIT to assess oxygen requirement for air travel. HIT SpO(2) can be estimated from FVC % predicted, resting SpO(2) and post-exercise SpO(2) using a linear regression model. |
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Authors:
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Ivan T Ling; Bhajan Singh; Alan L James; David R Hillman |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
Affiliation:
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Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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