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Vital capacity and oxygen saturation at rest and after exercise predict hypoxemia during hypoxic inhalation test in patients with respiratory disease.
MedLine Citation:
PMID:  23278952     Owner:  NLM     Status:  Publisher    
BACKGROUND & OBJECTIVE: The hypoxic inhalation test (HIT) accurately predicts air travel hypoxemia, but availability is limited. We assessed whether oxygen saturation (SpO(2) ) during hypoxic inhalation test (HIT) can be predicted by simple measures of lung function and exercise induced hypoxemia. METHODS: Analysis of all patients who had HIT and lung function testing between January 2005 and April 2010. Prior to HIT, SpO(2) on room air was measured at rest and after 2 minutes of moderate exercise. HIT was conducted using FiO(2) 0.14 (simulating PiO(2) at 10,000ft altitude) and SpO(2) was measured after equilibration of ≥5 minutes. The relationships between SpO(2) during HIT (HIT SpO(2) ) and resting SpO(2) , post-exercise SpO(2) , gas exchange (DLCO) and ventilatory capacity were examined. Linear regression was performed to identify significant predictors of HIT SpO(2) . RESULTS: 137 patients were studied: 70 had COPD, 43 interstitial lung disease (ILD) and 20 extra-pulmonary restriction (EPR). All patients with HIT SpO(2) ≤85% had post-exercise SpO(2) <95% (n=24 (18%)). HIT SpO(2) correlated best with post-exercise SpO(2) overall and in ILD and EPR subgroups (r=0.69, 0.76 and 0.61, p<0.01). Linear regression identified FVC % predicted, resting SpO(2) , and post-exercise SpO(2) as independent predictors of HIT SpO(2) . CONCLUSIONS: In patients with respiratory disease, post-exercise SpO(2) ≥95% on room air may be used to exclude the need for HIT to assess oxygen requirement for air travel. HIT SpO(2) can be estimated from FVC % predicted, resting SpO(2) and post-exercise SpO(2) using a linear regression model.
Ivan T Ling; Bhajan Singh; Alan L James; David R Hillman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-21
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
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