Document Detail


Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swine.
MedLine Citation:
PMID:  21330945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study determined the effects of serial, normovolemic, stepwise exchange transfusions with either 6% human serum albumin (HSA) or the hemoglobin-based oxygen carrier, HBOC-201, on tissue oxygenation of the heart, brain, and kidney in intact anaesthetized pigs. Exchange transfusions to 10%, 30%, and 50% of the pigs' total blood volume were completed at a withdrawal rate of 1.0 mL·kg(-1)·min(-1) followed by an infusion rate of 0.5 mL·kg(-1)·min(-1) of HBOC-201 or iso-oncotically matched 6% HSA. Measurements included invasive systemic hemodynamic (blood pressures, left ventricular end-diastolic pressure), hematolic (hemoglobin, hematocrit, methemoglobin), acid-base (pH, PCO2), and biochemistry (serum lactate) measurements. Brain and kidney tissue oxygenation (tPO2) was determined by electron paramagnetic resonance and heart tPO2 by O2 sensitive fiberoptic probe. The main results demonstrated that tPO2 after HBOC-201 remained stable despite significant decreases in hematocrit and changing hemodynamics. In vivo tPO2 measurements (heart tPO2 average ≥22 mmHg, brain tPO2 average ≥8 mmHg, and kidney tPO2 average ≥10 mmHg) were maintained in all groups at all times. Blood pressures were 20 to 30 mmHg higher after HBOC-201 compared with HSA controls. Heart rate and left ventricular end-diastolic pressure were not different among treatment groups. In conclusion, the administration of HBOC-201 maintained tPO2 in three vital organs after profound hemodilution.
Authors:
William W Muir; Govindasamy Ilangovan; Jay L Zweier; Paula F Moon-Massat; Virginia T Rentko
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  35     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-09-02     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  United States    
Other Details:
Languages:  eng     Pagination:  597-603     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Blood Substitutes / administration & dosage*
Brain / blood supply*
Coronary Vessels / metabolism*
Exchange Transfusion, Whole Blood*
Hematocrit
Hemodilution
Hemodynamics / drug effects
Hemoglobins / administration & dosage*
Humans
Kidney / blood supply*
Myocardium / metabolism*
Oxygen / blood,  metabolism*
Partial Pressure
Serum Albumin / administration & dosage*
Sus scrofa
Grant Support
ID/Acronym/Agency:
EB0890/EB/NIBIB NIH HHS; EB4900/EB/NIBIB NIH HHS; R01 EB000890/EB/NIBIB NIH HHS; R01 EB000890-04/EB/NIBIB NIH HHS; R01 EB004900/EB/NIBIB NIH HHS; R01 EB004900-04/EB/NIBIB NIH HHS; R01 HL038324/HL/NHLBI NIH HHS; R01 HL038324-20/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/HBOC 201; 0/Hemoglobins; 0/Serum Albumin; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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