| Visualizing retinotopic half-wave rectified input to the motion detection circuitry of Drosophila. | |
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MedLine Citation:
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PMID: 20622873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the visual system of Drosophila, photoreceptors R1-R6 relay achromatic brightness information to five parallel pathways. Two of them, the lamina monopolar cells L1 and L2, represent the major input lines to the motion detection circuitry. We devised a new method for optical recording of visually evoked changes in intracellular Ca2+ in neurons using targeted expression of a genetically encoded Ca2+ indicator. Ca2+ in single terminals of L2 neurons in the medulla carried no information about the direction of motion. However, we found that brightness decrements (light-OFF) induced a strong increase in intracellular Ca2+ but brightness increments (light-ON) induced only small changes, suggesting that half-wave rectification of the input signal occurs. Thus, L2 predominantly transmits brightness decrements to downstream circuits that then compute the direction of image motion. |
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Authors:
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Dierk F Reiff; Johannes Plett; Marco Mank; Oliver Griesbeck; Alexander Borst |
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16298413 - Hierarchical integration of individual motions in locally paired-dot stimuli. 1509693 - The perception of globally coherent motion. 2348023 - Two-dimensional sound localization by human listeners. |
Publication Detail:
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Type: Journal Article Date: 2010-07-11 |
Journal Detail:
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Title: Nature neuroscience Volume: 13 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 973-8 Citation Subset: IM |
Affiliation:
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Max Planck Institute of Neurobiology, Martinsried, Germany. reiff@neuro.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Drosophila Evoked Potentials, Visual / physiology Motion Perception / physiology* Photic Stimulation Photoreceptor Cells / cytology, physiology* Visual Pathways / cytology, physiology* |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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