| Visualizing receptors for neurotransmitters in the human brain with autoradiography. | |
| | |
MedLine Citation:
|
PMID: 2546100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with non-invasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool. |
| | |
Authors:
|
J M Palacios; G Chinaglia; A Probst |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurosurgical review Volume: 12 ISSN: 0344-5607 ISO Abbreviation: Neurosurg Rev Publication Date: 1989 |
Date Detail:
|
Created Date: 1989-08-17 Completed Date: 1989-08-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7908181 Medline TA: Neurosurg Rev Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 11-20 Citation Subset: IM |
Affiliation:
|
Preclinical Research, Sandoz Ltd, Basel, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autoradiography Brain Chemistry* Brain Diseases / metabolism Humans Receptors, Neurotransmitter / analysis* |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Neurotransmitter |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proximodistal gradients of the postjunctional folds at the frog neuromuscular junction: a scanning e...
Next Document: Computer tomographic assessment of perifocal edema surrounding tumors of the cerebral cortex.