| Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart. | |
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MedLine Citation:
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PMID: 22614494 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n=5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias. |
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Authors:
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Rebecca M Smith; Adam J Black; Saalini S Velamakanni; Taner Akkin; Elena G Tolkacheva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Applied optics Volume: 51 ISSN: 1539-4522 ISO Abbreviation: Appl Opt Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0247660 Medline TA: Appl Opt Country: United States |
Other Details:
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Languages: eng Pagination: 2713-21 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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