Document Detail


Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart.
MedLine Citation:
PMID:  22614494     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n=5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.
Authors:
Rebecca M Smith; Adam J Black; Saalini S Velamakanni; Taner Akkin; Elena G Tolkacheva
Related Documents :
10994734 - The role of fatty acids in cardiac imaging.
22117254 - Subvalvular membrane on the left ventricular outflow tract: multidetector computerised ...
16583314 - Adrenomedullin: molecular mechanisms and its role in cardiac disease.
25236884 - Energy metabolic re-programming in the hypertrophied and early stage failing heart: a m...
1347484 - Internal mammary artery angiography should be a routine component of diagnostic coronar...
17910744 - Role of echocardiography in diagnosis and risk stratification in heart failure with lef...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied optics     Volume:  51     ISSN:  1539-4522     ISO Abbreviation:  Appl Opt     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247660     Medline TA:  Appl Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2713-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gated viewing laser imaging with compressive sensing.
Next Document:  Numerical simulation of a dual frequency all-optical flip-flop based on a nonlinear semiconductor di...