Document Detail

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart.
MedLine Citation:
PMID:  22614494     Owner:  NLM     Status:  In-Data-Review    
Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n=5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.
Rebecca M Smith; Adam J Black; Saalini S Velamakanni; Taner Akkin; Elena G Tolkacheva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied optics     Volume:  51     ISSN:  1539-4522     ISO Abbreviation:  Appl Opt     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247660     Medline TA:  Appl Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2713-21     Citation Subset:  IM    
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