| Visualizing the functional diversification of CD8+ T cell responses in lymph nodes. | |
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MedLine Citation:
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PMID: 20850354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD8(+) T cell responses generate effector cells endowed with distinct functional potentials but the contribution of early events in this process is unclear. Here, we have imaged T cells expressing a fluorescent reporter for the activation of the interferon-γ (IFN-γ) locus during priming in lymph nodes. We have demonstrated marked differences in the efficiency of gene activation during stable T cell-dentritic cell (DC) contacts, influenced in part by signal strength. Imaging the first cell division, we have demonstrated that heterogeneity in T cell functional potential was largely apparent as T cells initiated clonal expansion. Moreover, by analyzing the fate of single activated T cells ex vivo, we have provided evidence that these early differences resulted in clonal progenies with distinct functional properties. Thus, the early set of T cell-DC interactions in lymph nodes largely contribute to the heterogeneity of T cell responses through the generation of functionally divergent clonal progenies. |
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Authors:
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Hélène Beuneu; Fabrice Lemaître; Jacques Deguine; Hélène D Moreau; Isabelle Bouvier; Zacarias Garcia; Matthew L Albert; Philippe Bousso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunity Volume: 33 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 412-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Institut Pasteur, Unité des Dynamiques des Réponses Immunes, Département d'Immunologie, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD8-Positive T-Lymphocytes / immunology* Cell Communication Dendritic Cells / immunology Hematopoietic Stem Cells / physiology Interferon-gamma / genetics Lymph Nodes / immunology* Lymphocyte Activation Mice Mice, Inbred C57BL T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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82115-62-6/Interferon-gamma |
| Comments/Corrections | |
Comment In:
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Immunity. 2010 Sep 24;33(3):296-8
[PMID:
20870171
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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