Document Detail


Visualizing Biochemical Activities in Living Cells through Chemistry.
MedLine Citation:
PMID:  22289374     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The development of molecular probes to visualize cellular processes is an important challenge in chemical biology. One possibility to create such cellular indicators is based on the selective labeling of proteins with synthetic probes in living cells. Over the last years, our laboratory has developed different labeling approaches for monitoring protein activity and for localizing synthetic probes inside living cells. In this article, we review two of these labeling approaches, the SNAP-tag and CLIP-tag technologies, and their use for studying cellular processes.
Authors:
Luc Reymond; Gražvydas Lukinavičius; Keitaro Umezawa; Damien Maurel; Matthias A Brun; Anastasiya Masharina; Karolina Bojkowska; Birgit Mollwitz; Alberto Schena; Rudolf Griss; Kai Johnsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chimia     Volume:  65     ISSN:  0009-4293     ISO Abbreviation:  Chimia (Aarau)     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373152     Medline TA:  Chimia (Aarau)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  868-71     Citation Subset:  IM    
Affiliation:
Institute of Chemical Sciences and Engineering, NCCR Chemical Biology, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
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