Document Detail

Visualized sclerotherapy of varicose veins.
MedLine Citation:
PMID:  20590713     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The spread and movement of sclerosant after injection during sclerotherapy is difficult to monitor. OBJECTIVE: To develop a new visualization method that allows monitoring of sclerosant dosage and flow during sclerotherapy. METHODS: We used a photodynamic eye (PDE) to perform indocyanine green (ICG) imaging. ICG produces strong fluorescence detectable using PDE and allows monitoring of sclerosant spread through blood vessels in real time. We performed visualized sclerotherapy on 50 limbs, comprising high ligation and sclerotherapy (35 limbs), stripping and sclerotherapy (10 limbs), and sclerotherapy alone (5 limbs). RESULTS: In all cases, fluorescence imaging of the injected sclerosant was possible. No complications resulted from combining ICG and polidocanol in any of the patients, all of whom received follow-up evaluations at 1 week, 1 month, and 3 months after treatment. CONCLUSIONS: Our new method not only avoids the risk of radiation exposure, but also allows for simple observation of sclerosant range of access, determination of the dosage for each lesion, and accurate administration of therapy to target lesions. This method will contribute to further advances in sclerotherapy, given that it allows administration of sclerosant and visual confirmation of optimal injection dosage, speed, and movement of sclerosant after injection. The authors have indicated no significant interest with commercial supporters.
Mamoru Kikuchi; Ko Hosokawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36 Suppl 2     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1050-5     Citation Subset:  IM    
Department of Plastic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
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MeSH Terms
Aged, 80 and over
Coloring Agents / diagnostic use*
Fluorescent Dyes / diagnostic use*
Indocyanine Green / diagnostic use*
Leg / blood supply*
Middle Aged
Sclerosing Solutions / administration & dosage,  pharmacokinetics*
Sclerotherapy / methods*
Varicose Veins / therapy*
Reg. No./Substance:
0/Coloring Agents; 0/Fluorescent Dyes; 0/Sclerosing Solutions; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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