Document Detail

Visualization of thermal ablation lesions using cumulative dynamic contrast enhancement MRI.
MedLine Citation:
PMID:  23615319     Owner:  NLM     Status:  Publisher    
A novel robust and user friendly method for post-processing dynamic contrast enhanced (DCE) MRI data is presented, which provides reliable real-time delineation of the borders of thermal ablation lesions on low SNR images shortly after contrast agent injection without any model-based curve fitting. Some simple descriptors of the DCE process are calculated in a time efficient recursive manner and combined into a single image reflecting both current and previous enhancement states of each pixel, which allows robust discrimination between tissue areas with different perfusion properties. The resulting cumulative DCE (CDCE) images are shown to exhibit a strong correlation with histopathology and late gadolinium enhancement representations of the thermal damage in soft tissue. It is shown that the outer border of the non-perfused ablation lesion core on CDCE MRI corresponds to the histopathological lesion border. The described method has a potential not only to facilitate thermal ablation outcome assessment, but also to improve detection of infiltrative tumours and reduce the administered contrast agent dose in any DCE scans.
Andriy Shmatukha; Benu Sethi; Mohammed Shurrab; Sudip Ghate; Xiuling Qi; Jennifer Barry; Graham Wright; Eugene Crystal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-25
Journal Detail:
Title:  Physics in medicine and biology     Volume:  58     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  3321-3337     Citation Subset:  -    
Cardiac and Interventional Applied Science Laboratory, General Electric Healthcare, Toronto, Ontario, Canada.
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