| Visualization of light propagation in visible Chinese human head for functional near-infrared spectroscopy. | |
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MedLine Citation:
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PMID: 21529068 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Using the visible Chinese human data set, which faithfully represents human anatomy, we visualize the light propagation in the head in detail based on Monte Carlo simulation. The simulation is verified to agree with published experimental results in terms of a differential path-length factor. The spatial sensitivity profile turns out to seem like a fat tropical fish with strong distortion along the folding cerebral surface. The sensitive brain region covers the gray matter and extends to the superficial white matter, leading to a large penetration depth (>3 cm). Finally, the optimal source-detector separation is suggested to be narrowed down to 3-3.5 cm, while the sensitivity of the detected signal to brain activation reaches the peak of 8%. These results indicate that the cerebral cortex folding geometry actually has substantial effects on light propagation, which should be necessarily considered for applications of functional near-infrared spectroscopy. |
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Authors:
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Ting Li; Hui Gong; Qingming Luo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical optics Volume: 16 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 045001 Citation Subset: IM |
Affiliation:
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Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Wuhan, Hubei 430074 China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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