Document Detail


Visualization of high resolution spatial mass spectrometric data during acquisition.
MedLine Citation:
PMID:  23367185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mass Spectrometric Imaging (MSI) allows the generation of 2D ion density maps that help visualize molecules present in sections of tissues and cells. The combination of spatial resolution and mass resolution results in very large and complex data sets. New capabilities are necessary for efficient analysis and interpretation of this data. This work details the development and application of the capability to process, visualize, query, and analyze spatial mass spectrometry data. Applications include the generation of 2D maps for selected spectra, the manipulation of the heat maps, and the identification of spectral peaks. Heat maps are generated by projecting the sum of intensity vs. time spectra of each pixel for selected m/z value or range. These capabilities take the form of a new interactive software toolkit, MSI QuickView. This software approach is a significant advance over the previous state-of-the art methods that required the conversion of the RAW data using one software, manual assembly of the data, and visualization in another software.
Authors:
Mathew Thomas; Brandi S Heath; Julia Laskin; Dongsheng Li; Ellen Liu; Katrina Hui; Andrew P Kuprat; Kerstin Kleese van Dam; James P Carson
Related Documents :
19113205 - Moving boundary approximation for curved streamer ionization fronts: solvability analysis.
23871735 - A novel lab-scale screen extruder for studying extrusion-spheronisation.
12933515 - Combining diagnostic test results to increase accuracy.
23270375 - Statistical inference from multiple itraq experiments without using common reference st...
17173695 - Constructing indices representing supportiveness of the physical environment for walkin...
19292645 - Generalization of the event-based carnevale-hines integration scheme for integrate-and-...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-24     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5545-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Automation
Humans
Mass Spectrometry / methods*
Principal Component Analysis
Software

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of genes for complex diseases by integrating multiple types of genomic data.
Next Document:  Building phylogenetic trees by using gene Nucleotide Genomic Signals.