| Visualization of flow patterns from stents and stent-grafts in an in vitro flow-model. | |
| | |
MedLine Citation:
|
PMID: 9788139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE AND OBJECTIVES: The authors determine flow characteristics and pressure gradients of different stents and stent grafts in an in vitro flow-model. METHODS: Five vascular stents (Memotherm, Cragg, two Palmaz P308, Strecker, and Wall) and one stent graft (Cragg EndoPro System 1), equal in length (60 mm) and diameter (10 mm), were deployed in a closed flow-model. The inner diameter of the tube measured 9 mm. Flow at 1.5 L/min, 6 L/min, and 10 L/min was simulated. Flow patterns were visualized by anionic particles illuminated with two Helium-Neon lasers. Laminary flow characteristics and pre-/poststent pressure gradients were determined in either expanded stent, 25% stenosis, or 50% stenosis. RESULTS: Stent implantation induced a decrease of laminary flow compared with an unstented tube with and without concentric 25% stenosis (P < 0.01) at all flow rates and an increase of pressure gradients compared with an unstented tube for flow rates greater than 1.5 L/min (P < 0.01) (except for Cragg EndoPro System 1 stent, which revealed an increase of the pressure gradient at a flow rate of 1.5 L/min [P < 0.01]). Memotherm stent permitted maximum of laminary flow at all flow rates and stenoses (expanded: 79.50% at 1.5 L/min to 69.90% at 10 L/min; P < 0.01). Memotherm and Palmaz permitted lowest pressure gradients (P < 0.01). All of the endoprostheses demonstrated laminary flow at 50% stenosis. CONCLUSIONS: The investigated stents and stent grafts showed different severity of flow disturbances and pressure gradients at different graded stenoses. Inadequate stent depolyment bears the risk of creating less laminary flow and pathologic pressure gradients. Because flow disturbances and pressure gradients may influence neointimal hyperplasia, stent design and completeness of stent unfolding are important regarding the appearance of postinterventional restenoses. |
| | |
Authors:
|
S Müller-Hülsbeck; H Schwarzenberg; F Wesner; R Drost; C C Glüer; M Heller |
Related Documents
:
|
9046189 - Blood flow measurement using a highly filled carbon polymer sandwich sensor and an elas... 2222769 - Blood irradiation: rationale and technique. 2757149 - Beneficial effects of banding on venous intimal-medial hyperplasia in arteriovenous loo... 14621809 - Activation of the alternative pathway of complement is an important component of hypera... 11152099 - The interrelationship between portal and arterial blood flow after adult to adult livin... 6979439 - Blood velocity, flow and dimensions of aortocoronary venous bypass grafts in the postop... 3075609 - Pulmonary blood velocity profile variability in open-chest dogs: influence of acutely a... 17763189 - Regional distribution of blood flow during proximal aortic cross-clamping: an experimen... 1111489 - Teratogenicities of ophthalmic drugs. ii. teratogenicities and tissue accumulation of t... |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
|
Title: Investigative radiology Volume: 33 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1998 Oct |
Date Detail:
|
Created Date: 1999-01-21 Completed Date: 1999-01-21 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 762-70 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University Hospital, Kiel, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Biomechanics Blood Flow Velocity Blood Pressure Equipment Design Hemorheology Humans Iliac Artery / physiology* Stents* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polylysine-Gd-DTPAn and polylysine-Gd-DOTAn coupled to anti-CEA F(ab')2 fragments as potential immun...
Next Document: Practical evaluation of comparative modelling and threading methods.