Document Detail

Visualization of deep veins and detection of deep vein thrombosis (DVT) with balanced turbo field echo (b-TFE) and contrast-enhanced T1 fast field echo (CE-FFE) using a blood pool agent (BPA).
MedLine Citation:
PMID:  20099355     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess image quality, vessel visualization, preliminary diagnostic properties, and interobserver variability of a novel balanced turbo field echo (b-TFE) sequence and contrast-enhanced T1 fast field echo (CE-FFE) sequence with blood pool agent (BPA).
MATERIALS AND METHODS: A total of 15 healthy volunteers and six patients with ultrasound-verified proximal deep vein thrombosis (DVT) were examined from the inferior vena cava (IVC) to the proximal calf veins.
RESULTS: The great majority of deep veins were completely visualized on both sequences. In healthy volunteers the IVC was completely visualized in five b-TFE and 11 CE-FFE scans, and partially in seven b-TFE and four CE-FFE scans (P = 0.008). Poorest image quality was in the pelvis. Contrast-to-noise ratio (CNR) was higher on b-TFE compared to CE-FFE, with significant difference in calf images (P = 0.036). Sensitivity was 100% for proximal DVT with both methods. Specificity was 70% (CE-FFE) and 80% (b-TFE) for proximal femoral DVT; 100% in distal femoral. Interobserver reliability was kappa 1.0 (b-TFE), 0.9 (CE-FFE) for proximal, and overall poor for distal DVT.
CONCLUSION: Contrast-enhancement did not add valuable information in visualizing deep veins of the lower limbs compared to b-TFE, though the IVC was slightly better visualized. Diagnostic properties and interobserver reliability of both sequences were good for proximal DVT and poor for distal DVT.
Tone Enden; Tryggve H Storås; Anne Negård; Ylva Haig; Leiv Sandvik; Kjell-Inge Gjesdal; Per Morten Sandset; Nils-Einar Kløw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  31     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-15     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  416-24     Citation Subset:  IM    
Faculty of Medicine, University of Oslo, Oslo, Norway.
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MeSH Terms
Contrast Media
Gadolinium / diagnostic use*
Image Enhancement / methods*
Magnetic Resonance Angiography / methods*
Middle Aged
Organometallic Compounds / diagnostic use*
Reproducibility of Results
Sensitivity and Specificity
Veins / pathology*
Venous Thrombosis / pathology*
Young Adult
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 7440-54-2/Gadolinium; XM33Q67UVH/gadofosveset trisodium

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