| Visualization of coronary plaque in type 2 diabetes mellitus patients using a new 40MHz intravascular ultrasound imaging system. | |
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MedLine Citation:
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PMID: 21890326 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Previous epidemiological studies demonstrated plaque vulnerability to be high in diabetic patients. iMap-intravascular ultrasound (IVUS) is a recently developed radiofrequency 40MHz IVUS imaging system for tissue characterization. This study aimed to characterize coronary plaque in target lesions of diabetic patients using iMap-IVUS. METHODS: We studied 175 treated vessels in 146 patients with stable angina pectoris and analyzed plaque components of culprit lesions by iMAP-IVUS. Patients were divided into 2 groups: non-diabetic (non-DM: 112 vessels, 93 patients) and diabetic (DM: 63 vessels, 53 patients). RESULTS: In gray-scale IVUS 2D analysis, there were no differences in IVUS parameters. In 3D analysis, the DM group tended to have a larger plaque volume (p=0.07) and plaque burden (p=0.10). At minimum lumen sites, the absolute lipidic and necrotic areas (0.84±0.44mm(2) vs. 0.58±0.41mm(2), p<0.001, and 2.42±1.65mm(2) vs. 1.46±1.76mm(2), p<0.001, respectively) and percent lipidic and necrotic areas were significantly greater in the DM than in the non-DM group (8.39±3.38% vs. 5.25±2.30%, p<0.0001, and 23.65±11.54% vs. 12.99±10.71%, p<0.0001, respectively). In addition, the absolute lipidic and necrotic volumes (11.75±10.59mm(3) vs. 8.18±6.24mm(3), p<0.01, and 29.99±28.90mm(3) vs. 19.44±19.35mm(3), p<0.01, respectively) and percent lipidic and necrotic volumes were significantly greater in the DM than in the non-DM group (6.27±1.92% vs. 5.13±1.82%, p<0.0001, and 16.54±7.56% vs. 12.08±6.05%, p<0.0001, respectively). CONCLUSION: Characterization of coronary plaque by iMAP-IVUS in diabetic patients showed increased lipidic amount and necrotic plaque volume relative to subjects without DM. |
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Authors:
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Tadashi Araki; Masato Nakamura; Makoto Utsunomiya; Kaoru Sugi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-2 |
Journal Detail:
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Title: Journal of cardiology Volume: - ISSN: 1876-4738 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-17-6, Ohashi, Meguro-ku, Tokyo 153-8515, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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