| Visualising Neuroinflammation in Post-Stroke Patients: A comparative PET study with the TSPO Molecular Imaging Biomarkers [(11)C]PK11195 and [(11)C]vinpocetine. | |
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MedLine Citation:
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PMID: 22074478 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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With the main objective of comparing the prospective diagnostic power of two 11C-labelled molecular imaging biomarkers with affinity for TSPO and used for the visualisation of activated microglia after a stroke, we measured with positron emission tomography (PET) in four post-stroke patients the regional brain uptake and binding potential of [(11)C]vinpocetine and [(11)C]PK11195. Percentage standard uptake values (%SUV) and binding potential (BP(ND)) were used as outcome measures. The total peak brain uptake value and average global brain uptake value were higher for [(11)C]vinpocetine than for [(11)C]PK11195. The regional %SUV values were significantly higher for [(11)C]vinpocetine than for [(11)C]PK11195 in the hemispheres as well as in almost all standard brain regions. The %SUV values of [(11)C]vinpocetine were higher in the peri-infarct zone than in the ischaemic core, however, the difference did not prove to be significant. There was basically no difference in %SUV values between the ischaemic core and the peri-infarct zone for [(11)C]PK11195. The BPND values for [(11)C]vinpocetine were higher in all standard regions than those for [(11)C]PK11195, but the difference was not significant between them. The BPND values of [(11)C]vinpocetine were higher in the peri-infarct zone than in the ischaemic core, however, the difference did not prove to be significant. A comparative analysis of the two ligands indicates that [(11)C]vinpocetine shows a number of favourable characteristics over [11C]PK11195, but to demonstrate that it may serve as a prospective molecular imaging biomarker of microglia activation in post-stroke patients, further studies are required. |
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Authors:
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Balázs Gulyás; Miklós Tóth; Adám Vas; Evgeni Shchukin; Konstantinos Kostulas; Jan Hillert; Christer Halldin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: Current radiopharmaceuticals Volume: - ISSN: 1874-4729 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468718 Medline TA: Curr Radiopharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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