| Visual outcome in Japanese patients with Acanthamoeba keratitis. | |
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MedLine Citation:
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PMID: 22241017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To identify prognostic factors affecting visual outcome in Acanthamoeba keratitis (AK) treated with topical chlorhexidine gluconate (CHG). METHODS: A total of 35 eyes in 34 patients with AK were treated with 0.02% topical CHG. Patients were divided into two groups according to the final visual outcome: Group 1, final visual acuity (VA) of 20/25 or greater (22 eyes); Group 2, less than 20/25 (13 eyes). We compared these groups and evaluated the effectiveness of topical CHG compared with outcomes in previous reports. RESULTS: Ring infiltrate was observed more often in Group 2 (4.5% vs 61.5%, OR 33.6, 95% confidence interval (CI) 3.4-333.9, P<0.01). The duration between onset and diagnosis of AK was significantly longer (24.9 days vs 48.4 days, OR 1.03, 95% CI 1.00-1.06, P = 0.04) and VA at initial examination (log MAR) significantly lower (0.47 vs 1.59, OR 25.5, 95% CI 3.4-186.7, P<0.01) in Group 2 (visual outcome <20/25). Multivariate analysis revealed that only VA at initial examination was independently associated with worse visual outcome (adjusted OR 24.5, 95% CI 1.9-312.6, P=0.01). Seventeen (85.0%) of the 20 eyes diagnosed within 1 month and 24 (82.8%) of 29 eyes diagnosed within 2 months achieved a VA of 20/40 or greater. CONCLUSION: VA at initial examination was the most predictive factors for final visual outcome in AK. Topical CHG was comparably effective to other treatments, including polyhexamethyl biguanide and propamidine isethionate. |
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Authors:
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K Yamazoe; Y Yamamoto; S Shimazaki-Den; J Shimazaki |
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Publication Detail:
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Type: Journal Article Date: 2012-01-13 |
Journal Detail:
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Title: Eye (London, England) Volume: 26 ISSN: 1476-5454 ISO Abbreviation: Eye (Lond) Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-12 Completed Date: 2012-06-05 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 517-22 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Tokyo Dental College, Chiba, Japan. kyamazoe1528@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthamoeba Keratitis
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drug therapy*,
physiopathology Adolescent Adult Anti-Infective Agents, Local / therapeutic use* Chlorhexidine / analogs & derivatives*, therapeutic use Female Humans Japan Male Middle Aged Prognosis Treatment Outcome Visual Acuity / drug effects*, physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 18472-51-0/chlorhexidine gluconate; 55-56-1/Chlorhexidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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