Document Detail

Visual mutations reveal opposing effects of illumination on arousal in Drosophila.
MedLine Citation:
PMID:  18430958     Owner:  NLM     Status:  MEDLINE    
The effect of illumination on alertness can be assessed by comparing the efficacy of an anesthetic under light vs. dark conditions. Results from such tests on wild-type flies and visual mutants demonstrate that, surprisingly, light has both positive and negative influences on arousal. These dual effects may explain aspects of the fly's daily activity and have potential clinical implications.
Yuzhong Cheng; Howard A Nash
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Genetics     Volume:  178     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-23     Completed Date:  2008-06-27     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2413-6     Citation Subset:  IM    
Laboratory of Molecular Biology, National Institutes of Mental Health, Bethesda, Maryland 20892-3736, USA.
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MeSH Terms
Arousal / radiation effects*
Dose-Response Relationship, Radiation
Drosophila melanogaster / genetics*,  radiation effects*
Mutation / genetics*
Vision, Ocular / genetics*

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