Document Detail


Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys.
MedLine Citation:
PMID:  11719199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To reduce the information gap between human neuroimaging and macaque physiology and anatomy, we mapped fMRI signals produced by moving and stationary stimuli (random dots or lines) in fixating monkeys. Functional sensitivity was increased by a factor of approximately 5 relative to the BOLD technique by injecting a contrast agent (monocrystalline iron oxide nanoparticle [MION]). Areas identified as motion sensitive included V2, V3, MT/V5, vMST, FST, VIP, and FEF (with moving dots), as well as V4, TE, LIP, and PIP (with random lines). These regions sensitive for moving dots are largely in agreement with monkey single unit data and (except for V3A) with human fMRI results. Moving lines activate some regions that have not been previously implicated in motion processing. Overall, the results clarify the relationship between the motion pathway and the dorsal stream in primates.
Authors:
W Vanduffel; D Fize; J B Mandeville; K Nelissen; P Van Hecke; B R Rosen; R B Tootell; G A Orban
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  32     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-23     Completed Date:  2002-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  565-77     Citation Subset:  IM    
Affiliation:
Laboratorium voor Neuro- en Psychofysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Belgium. wim.vanduffel@med.kuleuven.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Awareness
Behavior, Animal / physiology
Brain Mapping / methods
Contrast Media*
Ferrosoferric Oxide
Iron*
Macaca mulatta
Magnetic Resonance Imaging / methods*,  standards
Male
Motion Perception / physiology*
Oxides*
Parietal Lobe / physiology
Reproducibility of Results
Sensitivity and Specificity
Temporal Lobe / physiology
Visual Cortex / physiology*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Oxides; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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