Document Detail

Visual loss with Langerhans cell histiocytosis: multifocal central nervous system involvement.
MedLine Citation:
PMID:  10098549     Owner:  NLM     Status:  MEDLINE    
A 42-year-old woman with a 6-year history of diabetes insipidus and progressive hypersomnolence presented with visual loss. Neuroimaging showed infiltration in the hypothalamus, the optic nerve, and the chiasm, as well as multiple lesions in other areas of the brain parenchyma. Biopsy showed Langerhans cell histiocytosis. This is an unusual presentation of Langerhans cell histiocytosis, involving the visual pathways without manifestations outside of the central nervous system. The differential diagnosis and the magnetic resonance imaging findings will be discussed.
O M Job; N J Schatz; J S Glaser
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  19     ISSN:  1070-8022     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-23     Completed Date:  1999-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Department of Neuro-Ophthalmology, Mercy Neuro-Science Institute, Miami, Florida 33133, USA.
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MeSH Terms
Administration, Oral
Brain Diseases / complications*,  diagnosis,  drug therapy
Histiocytosis, Langerhans-Cell / complications*,  diagnosis,  drug therapy
Infusions, Intravenous
Magnetic Resonance Imaging
Methylprednisolone / therapeutic use
Optic Chiasm / pathology
Optic Nerve / pathology
Prednisone / therapeutic use
Vision Disorders / diagnosis,  drug therapy,  etiology*
Visual Acuity
Visual Fields
Visual Pathways / pathology
Reg. No./Substance:
53-03-2/Prednisone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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