Document Detail


Visual impairment in Parkinson's disease treated with amantadine: case report and review of the literature.
MedLine Citation:
PMID:  17509924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 61-year-old man with Parkinson's disease (PD) developed sudden-onset visual impairment after initiation of amantadine treatment. Ophthalmologic examination revealed corneal endothelial edema. Discontinuation of amantadine resulted in rapid improvement of visual acuity. A review of the literature indicated only a few reports of amantadine-associated corneal dysfunction in patients with neurological disorders as well as influenza syndrome, but none with PD. Amantadine-associated visual impairment in PD could be possibly overlooked, since PD mainly affects elderly people who often develop aging-related ocular changes. The present report alerts neurologists and physicians in general to the peculiar ophthalmologic side effect of amantadine.
Authors:
Shin-ichiro Kubo; Akira Iwatake; Nobuyuki Ebihara; Akira Murakami; Nobutaka Hattori
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-05-16
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  14     ISSN:  1353-8020     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  166-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. skubo@med.juntendo.ac.jp <skubo@med.juntendo.ac.jp>
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MeSH Terms
Descriptor/Qualifier:
Amantadine / therapeutic use*
Antiparkinson Agents / therapeutic use*
Cornea / pathology
Endothelium, Corneal / pathology
Humans
Male
Middle Aged
Parkinson Disease / complications*
Vision Disorders / drug therapy*,  etiology*
Visual Acuity
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 768-94-5/Amantadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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