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Visual functional magnetic resonance imaging of preterm infants.
MedLine Citation:
PMID:  22715952     Owner:  NLM     Status:  Publisher    
Aim  The aim of this study was to determine the feasibility of undertaking visual functional magnetic resonance imaging (fMRI) in very preterm children. Method  Forty-seven infants born at less than 32 weeks gestational age (25 males, 22 females; mean (SD) age at birth 28.8wks [1.9]) were scanned using 1.5T MRI as part of a longitudinal neuroimaging study. These infants were scanned at preterm age (within 2wks of birth) and at term-equivalent age. Quantitative T2* data and fMRI in response to visual stimuli (flashing strobe) were acquired in this population. T2* values were compared at preterm age and at term-equivalent age using a two-tailed t-test. A general linear model was used to evaluate occipital lobe response to visual stimuli. Results  T2* values were significantly higher at preterm age than at term-equivalent age in both the medial and lateral occipital lobes (preterm infants: 187.2ms and 198.4ms respectively; term infants: 110.9ms and 133.2ms respectively; p<0.002). Significant positive occipital lobe activation (q<0.01) was found in 3 out of 65 (5%) fMRIs carried out at preterm age and in 19 out of 26 (73%) scans carried out at term-equivalent age. Interpretation  Visual stimuli do not elicit a reliable blood oxygen level-dependent (BOLD) response in very preterm infants during the preterm period. This suggests that BOLD fMRI may not be the appropriate modality for investigating occipital lobe function in very preterm infants.
Wayne Lee; Elizabeth J Donner; Revital Nossin-Manor; Hilary Ea Whyte; John G Sled; Margot J Taylor
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-21
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  -     ISSN:  1469-8749     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
 Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON.  Department of Medical Biophysics, University of Toronto, Toronto, ON.  Department of Medical Biophysics, University of Toronto, Toronto, ON  Department of Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON.  Department of Neonatology, Hospital for Sick Children, Toronto, ON.  Department of Physiology & Experimental Medicine, Toronto Centre for Phenogenomics, Toronto, ON, Canada.
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