Document Detail

Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial.
MedLine Citation:
PMID:  12838196     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Breast-fed infants receive docosahexaenoic acid (DHA) and arachidonic acid (ARA) in their diet. Upon weaning, infants lose this dietary source of long-chain polyunsaturates because many commercial formulas do not contain these important constituents for neural membrane biogenesis. We evaluated the benefits of postweaning dietary supplementation of DHA + ARA on visual maturation. STUDY DESIGN: Healthy term infants (n = 61) were breast-fed to 4 to 6 months, then were randomly assigned to commercial formula or formula supplemented with DHA (0.36%) + ARA (0.72%). Measurements of red blood cell (RBC) fatty acids, visually evoked potential (VEP) acuity, and stereoacuity were done before and after weaning. RESULTS: At 1 year of age, RBC-DHA in the commercial formula-fed group was reduced by 50% from the weaning level, whereas there was a 24% increase in the DHA + ARA-supplemented group. The primary outcome measure, VEP acuity, was significantly more mature in supplemented infants at 1 year of age. Elevated RBC-DHA levels were associated with more mature VEP acuity. There were no significant diet-related differences in stereoacuity. CONCLUSIONS: These data extend through the first year of life the critical period in which a dietary supply of DHA and ARA can contribute in optimizing visual development in term infants.
Dennis R Hoffman; Eileen E Birch; Yolanda S Castañeda; Sherry L Fawcett; Dianna H Wheaton; David G Birch; Ricardo Uauy
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  142     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  669-77     Citation Subset:  AIM; IM    
Retina Foundation of the Southwest, Dallas, Texas 75231, USA.
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MeSH Terms
Arachidonic Acid / administration & dosage*
Breast Feeding
Docosahexaenoic Acids / administration & dosage*
Erythrocytes / chemistry
Evoked Potentials, Visual
Fatty Acids / analysis
Infant Food*
Visual Acuity*
Grant Support
Reg. No./Substance:
0/Fatty Acids; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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