Document Detail


Visual field and intraocular pressure asymmetry in the low-pressure glaucoma treatment study.
MedLine Citation:
PMID:  17141318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore the relationship between asymmetric baseline intraocular pressure (IOP) and asymmetric visual field (VF) loss in the Low-Pressure Glaucoma Treatment Study. DESIGN: Randomized, multicenter, controlled clinical trial. PARTICIPANTS: Low-pressure glaucoma (LPG) patients 30 years or older were identified. Exclusion criteria included an untreated pressure > 21 mmHg, advanced VF loss, and contraindications to study medications. INTERVENTIONS: A baseline VF was created using the average of 2 reliable Humphrey full-threshold examinations. A baseline diurnal IOP curve was performed without IOP-lowering medication. MAIN OUTCOME MEASURES: Mean diurnal, peak, trough, IOP range (peak - trough), and standard deviation (SD) of IOP measurements, and mean deviation (MD) and corrected pattern SD (CPSD) of VF examinations. RESULTS: One hundred ninety patients were enrolled (mean age, 64.9+/-10.7 years). Mean deviation and CPSD were not correlated with mean, peak, trough, or peak minus trough (P - T) IOP (Ps = 0.2-0.9). Among patients with unilateral VF loss (n = 53 [27.9%]), there were no differences (Ps = 0.3-0.9) in any IOP parameter between the normal VF eye and fellow glaucomatous eyes. Among patients with bilateral VF loss (n = 137 [72.1%]), mean, peak, trough, and P - T IOPs were similar in eyes with a better VF MD compared with eyes with a worse VF MD (Ps = 0.2-0.7). Cross-classified contingency tables demonstrated no relationship (Ps = 0.1-0.3) between IOP and VF MD or CPSD using chi-square analysis. CONCLUSIONS: Intraocular pressure asymmetry is unrelated to VF asymmetry in the Low-Pressure Glaucoma Treatment Study, suggesting an unclear pathogenic relationship between IOP and glaucomatous damage in eyes with LPG.
Authors:
David S Greenfield; Jeffrey M Liebmann; Robert Ritch; Theodore Krupin;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-11-30
Journal Detail:
Title:  Ophthalmology     Volume:  114     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-03-13     Revised Date:  2008-03-20    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  460-5     Citation Subset:  IM    
Affiliation:
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, Florida 33418, USA. dgreenfield@med.miami.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / therapeutic use
Adrenergic beta-Antagonists / therapeutic use
Adult
Aged
Aged, 80 and over
Aging
Circadian Rhythm*
Double-Blind Method
Female
Glaucoma / drug therapy,  physiopathology*
Humans
Intraocular Pressure*
Male
Middle Aged
Quinoxalines / therapeutic use
Timolol / therapeutic use
Visual Fields*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Antagonists; 0/Quinoxalines; 26839-75-8/Timolol; 59803-98-4/brimonidine
Comments/Corrections
Comment In:
Ophthalmology. 2008 Mar;115(3):590-1; author reply 591-2   [PMID:  18319115 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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