| Visual field and intraocular pressure asymmetry in the low-pressure glaucoma treatment study. | |
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MedLine Citation:
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PMID: 17141318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To explore the relationship between asymmetric baseline intraocular pressure (IOP) and asymmetric visual field (VF) loss in the Low-Pressure Glaucoma Treatment Study. DESIGN: Randomized, multicenter, controlled clinical trial. PARTICIPANTS: Low-pressure glaucoma (LPG) patients 30 years or older were identified. Exclusion criteria included an untreated pressure > 21 mmHg, advanced VF loss, and contraindications to study medications. INTERVENTIONS: A baseline VF was created using the average of 2 reliable Humphrey full-threshold examinations. A baseline diurnal IOP curve was performed without IOP-lowering medication. MAIN OUTCOME MEASURES: Mean diurnal, peak, trough, IOP range (peak - trough), and standard deviation (SD) of IOP measurements, and mean deviation (MD) and corrected pattern SD (CPSD) of VF examinations. RESULTS: One hundred ninety patients were enrolled (mean age, 64.9+/-10.7 years). Mean deviation and CPSD were not correlated with mean, peak, trough, or peak minus trough (P - T) IOP (Ps = 0.2-0.9). Among patients with unilateral VF loss (n = 53 [27.9%]), there were no differences (Ps = 0.3-0.9) in any IOP parameter between the normal VF eye and fellow glaucomatous eyes. Among patients with bilateral VF loss (n = 137 [72.1%]), mean, peak, trough, and P - T IOPs were similar in eyes with a better VF MD compared with eyes with a worse VF MD (Ps = 0.2-0.7). Cross-classified contingency tables demonstrated no relationship (Ps = 0.1-0.3) between IOP and VF MD or CPSD using chi-square analysis. CONCLUSIONS: Intraocular pressure asymmetry is unrelated to VF asymmetry in the Low-Pressure Glaucoma Treatment Study, suggesting an unclear pathogenic relationship between IOP and glaucomatous damage in eyes with LPG. |
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Authors:
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David S Greenfield; Jeffrey M Liebmann; Robert Ritch; Theodore Krupin; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-11-30 |
Journal Detail:
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Title: Ophthalmology Volume: 114 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-27 Completed Date: 2007-03-13 Revised Date: 2008-03-20 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 460-5 Citation Subset: IM |
Affiliation:
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Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, Florida 33418, USA. dgreenfield@med.miami.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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therapeutic use Adrenergic beta-Antagonists / therapeutic use Adult Aged Aged, 80 and over Aging Circadian Rhythm* Double-Blind Method Female Glaucoma / drug therapy, physiopathology* Humans Intraocular Pressure* Male Middle Aged Quinoxalines / therapeutic use Timolol / therapeutic use Visual Fields* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Antagonists; 0/Quinoxalines; 26839-75-8/Timolol; 59803-98-4/brimonidine |
| Comments/Corrections | |
Comment In:
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Ophthalmology. 2008 Mar;115(3):590-1; author reply 591-2
[PMID:
18319115
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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