| Visual evoked potentials N75 and P100 latencies correlate with urinary delta-aminolevulinic acid, suggesting gamma-aminobutyric acid involvement in their generation. | |
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MedLine Citation:
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PMID: 8747849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pattern reversal visual evoked potentials were recorded from 31 subjects who were occupationally exposed to lead and 54 non-exposed controls. No significant effects of lead were observed in the general subject population. However, when only non-smokers (17 lead-exposed and 27 controls) were evaluated, significant effects were found. The P100, but not the N75, latency was significantly prolonged in the lead-exposed group, and this correlated with both blood lead level and age. Nevertheless, both the N75 and P100 latencies correlated with the concentration of delta-aminolevulinic acid (delta-ALA) in urine and age. This, at least in part, could be due to elevated delta-ALA levels competing at gamma-aminobutyric acid (GABA) receptor neurons. This is consistent with the fact that GABA receptor neurons are involved along the entire length of the visual pathway. The results indicate that lead affects neural function even at permitted levels of exposure, and that this level should be reduced. |
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Authors:
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B M Solliway; A Schaffer; H Pratt; N Mittelman; S Yannai |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 134 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-09-27 Completed Date: 1996-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 89-94 Citation Subset: IM |
Affiliation:
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Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminolevulinic Acid
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urine* Case-Control Studies Evoked Potentials, Visual / physiology* Humans Lead Poisoning / physiopathology*, urine Reaction Time / physiology Regression Analysis gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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106-60-5/Aminolevulinic Acid; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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