Document Detail

Visual evoked potential correlates of positive/negative symptoms in schizophrenia.
MedLine Citation:
PMID:  2310795     Owner:  NLM     Status:  MEDLINE    
Previous studies of schizophrenic patients have found evoked potential (EP) correlates of clinical symptomatology, including EP differences between subtypes of schizophrenia. In the current study, 14 medicated male schizophrenics underwent flash visual evoked potentials (VEP) and were clinically rated for positive and negative symptoms. We tested the hypothesis that positive symptoms would be associated with VEP latency reduction and negative symptoms with latency prolongation. Patients were divided into predominantly positive symptom and predominantly negative symptom groups using a combination of positive and negative symptom ratings. Patients with predominantly positive symptoms exhibited reduced latencies when compared with predominantly negative symptom patients. Similarly, significant negative correlations between positive symptom ratings and P200 latency variables were found. Correlations between negative symptom measures and P200 latencies (in the opposite direction) were also noted, but were less significant. These relationships persisted when confounders were statistically controlled for. The results are consistent with previous findings of evoked potential correlates of clinical symptomatology, especially those finding EP latency correlates of psychosis severity and affective blunting. The findings are discussed in relationship to concepts relevant to psychosis, including arousal, sensory gating, and the dopamine hypothesis.
S B Schwarzkopf; J S Lamberti; M Jiminez; C F Kane; M Henricks; H A Nasrallah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  27     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-10     Citation Subset:  IM    
Ohio State University College of Medicine, Columbus 43210-1228.
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MeSH Terms
Chronic Disease
Confounding Factors (Epidemiology)
Evoked Potentials, Visual*
Reaction Time
Schizophrenia / physiopathology*

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