| Visual evoked potential can be used to detect a prediabetic form of diabetic retinopathy in patients with diabetes mellitus type I. | |
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MedLine Citation:
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PMID: 20698126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the usefulness of visual evoked potential (VEP) testing in detecting retinal ganglion cell damage in patients with Diabetes Mellitus type I (DMI). VEP arise before diabetic retinopathy signs become ophthalmoscopically detectable. VEP testing was performed in 45 patients divided into three groups; 15 children with recently discovered DMI, 15 children with long-lasting DMI, and 15 healthy children as the control group. A statistically significant difference in VEP P100 wave amplitudes (Z = 4.02, p < 0.001) and latencies (Z = -4.66, p < 0.001) was found between children with established DMI and those with recently discovered DMI. Amplitude values decrease progressively and latency values increase progressively in children with DMI as the years pass. Progressive increases in VEP latency values are a direct sign of retinal ganglion cell damage, which takes place even before the first ophthalmoscopically detectable signs of diabetic retinopathy arise. Therefore, VEP should be considered as a valid method for detecting prediabetic retinopathy, which could contribute greatly to the prevention of diabetic retinopathy complications. |
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Authors:
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Dobrila Karlica; Davor Galetović; Milan Ivanisević; Veselin Skrabić; Ljubo Znaor; Darija Jurisić |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Collegium antropologicum Volume: 34 ISSN: 0350-6134 ISO Abbreviation: Coll Antropol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003354 Medline TA: Coll Antropol Country: Croatia |
Other Details:
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Languages: eng Pagination: 525-9 Citation Subset: IM |
Affiliation:
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Eye Clinic, Split University Hospital, Split, Croatia. dobrila.karlica@st.t-com.hr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Diabetes Mellitus, Type 1 / physiopathology* Diabetic Retinopathy / diagnosis*, physiopathology Disease Progression Evoked Potentials, Visual / physiology* Female Humans Male Prediabetic State / diagnosis*, physiopathology Reaction Time Reference Values |
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