Document Detail

Visual attention orienting in liver cirrhosis without overt hepatic encephalopathy.
MedLine Citation:
PMID:  8847996     Owner:  NLM     Status:  MEDLINE    
The attention system in patients with liver cirrhosis has not yet been fully investigated. We therefore studied visual attention orienting in cirrhotic patients without overt hepatic encephalopathy. Seventy cirrhotic patients without overt hepatic encephalopathy (aged 57 +/- 10 yr., mean +/- s.d.) and 55 controls (aged 49 +/- 12 yr.) were enrolled. Visual attention orienting was evaluated by a computerized neuropsychological test. The Reitan A test, commonly used to detect subclinical hepatic encephalopathy, was used to evaluate mental performance. Psychometric test scores were reduced in cirrhotics compared to controls (attention test: neutral condition = 495 +/- 149 vs. 401 +/- 98 msec; valid condition = 434 +/- 110 vs. 398 +/- 84 msec; invalid condition = 485 +/- 146 vs. 392 +/- 110 msec; p < 0.001; Reitan A test = 52 +/- 20 vs. 35 +/- 11 sec., p < 0.001). The attention effect of the cue was found both in controls and cirrhotics; however, it was significantly higher in cirrhotics than in controls (61 +/- 111 vs. 33 +/- 41 msec; p < 0.002). The attention effect was directly correlated with Reitan A test (r = 0.23, p = 0.05) in cirrhotics. In conclusion, in cirrhotic patients without overt hepatic encephalopathy, visual attention orienting was present and focusing to an indexed location had a higher effect on reaction time compared to controls, possibly because of reduced basal arousal.
P Amodio; P Marchetti; F Del Piccolo; G Sartori; M Prior; C Merkel; A Gatta
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Metabolic brain disease     Volume:  10     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  335-45     Citation Subset:  IM    
Institute of Clinical Medicine (SplenoEpatologia), University of Padova, Italy.
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MeSH Terms
Attention / physiology*
Hepatic Encephalopathy / physiopathology,  psychology*
Liver Cirrhosis / physiopathology,  psychology*
Liver Function Tests
Middle Aged
Neuropsychological Tests
Orientation / physiology*
Reaction Time / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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