Document Detail

Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation.
MedLine Citation:
PMID:  8317386     Owner:  NLM     Status:  MEDLINE    
Docosahexaenoic acid (DHA; 22:6n-3) is important for normal visual development. We hypothesized that preterm infants fed formulas with marine oil as a source of DHA would have better visual acuity than infants fed formulas without marine oil, as measured by the Teller Acuity Card procedure. Marine oil (P < 0.001) and age (P < 0.0001) influenced visual acuity, by repeated-measures analysis of variance (ANOVA) corrected for the effect of subject. Marine-oil-supplemented infants had better visual acuity than those fed standard formulas at 2 and 4 mo of age, by Fishers' least-squares difference (LSD). Acuity of both dietary groups improved through 6.5 mo of age, then plateaued. Through 4 mo of age, acuity was inversely related to oxygen supplementation (log10 h) and positively related to DHA status, by general-linear-models (GLM) analysis. After 4 mo of age, birth weight and gestational age were the only variables consistently related to visual acuity by GLM. We conclude that marine-oil-supplemented formula improved visual acuity of preterm infants through 4 mo of age by improving DHA status.
S E Carlson; S H Werkman; P G Rhodes; E A Tolley
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  58     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Tennessee, Memphis.
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MeSH Terms
Aging / physiology
Docosahexaenoic Acids / blood
Fish Oils / administration & dosage,  pharmacology*
Infant, Newborn
Infant, Premature / blood,  physiology*
Linear Models
Linolenic Acids / blood
Visual Acuity*
Reg. No./Substance:
0/Fish Oils; 0/Linolenic Acids; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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