| Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. | |
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MedLine Citation:
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PMID: 8317386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Docosahexaenoic acid (DHA; 22:6n-3) is important for normal visual development. We hypothesized that preterm infants fed formulas with marine oil as a source of DHA would have better visual acuity than infants fed formulas without marine oil, as measured by the Teller Acuity Card procedure. Marine oil (P < 0.001) and age (P < 0.0001) influenced visual acuity, by repeated-measures analysis of variance (ANOVA) corrected for the effect of subject. Marine-oil-supplemented infants had better visual acuity than those fed standard formulas at 2 and 4 mo of age, by Fishers' least-squares difference (LSD). Acuity of both dietary groups improved through 6.5 mo of age, then plateaued. Through 4 mo of age, acuity was inversely related to oxygen supplementation (log10 h) and positively related to DHA status, by general-linear-models (GLM) analysis. After 4 mo of age, birth weight and gestational age were the only variables consistently related to visual acuity by GLM. We conclude that marine-oil-supplemented formula improved visual acuity of preterm infants through 4 mo of age by improving DHA status. |
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Authors:
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S E Carlson; S H Werkman; P G Rhodes; E A Tolley |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 58 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-29 Completed Date: 1993-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 35-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Tennessee, Memphis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Docosahexaenoic Acids / blood Fish Oils / administration & dosage, pharmacology* Humans Infant, Newborn Infant, Premature / blood, physiology* Linear Models Linolenic Acids / blood Visual Acuity* |
| Chemical | |
Reg. No./Substance:
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0/Fish Oils; 0/Linolenic Acids; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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